Meta AnalysisID 2739
使用组胺-2受体拮抗剂是新生儿感染、坏死性小肠结肠炎和死亡的危险因素吗？
CRD42017060887
Is histamine-2 receptor antagonists use a risk factor for infection, necrotizing enterocolitis and mortality in neonates?
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Record Fields
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- Meta Analysis Id
- 2739
- Evidence Id
- 11297
- Core Evidence Id
- 11297
- Source Meta Analysis Id
- 2689
- Herb2 Meta Analysis Id
- HBMA002689
- Crd Id
- CRD42017060887
- Title
- Is histamine-2 receptor antagonists use a risk factor for infection, necrotizing enterocolitis and mortality in neonates?
- Review Question
- Is histamine-2 receptor antagonists use a risk factor for infection, necrotizing enterocolitis and mortality in neonates?
- Study Type Included
- Case-control studies, cohort studies and clinical trials.
- Condition Being Studied
- Histamine-2 receptor antagonists (H2RA) are frequently prescribed off-label to neonates admitted to neonatal intensive care units (NICU). Some studies show that the use of H2RA may predispose to infections in adults and older children, and possibly necrotising enterocolitis (NEC) in neonates, but this association has not been systematically examined.
- Participant
- Inclusion: all neonates hospitalized in a NICU who have or have not been exposed to ranitidine treatment. Exclusion: neonates born from mothers with trans-placental infection potential (i.e. human immunodeficiency virus, syphilis, hepatitis, toxoplasmosis, rubella and cytomegalovirus), neonates with congenital malformation (i.e, hydrocephalus, intestinal atresia, gastroschisis, meningoencephalocele, hydronephrosis), and neonates with genetic syndromes.
- Animal
- Human Disease Modelled
- Intervention
- Neonates who have been exposed to histamine-2 receptor antagonists.
- Comparator Control
- Neonates who have not been exposed to histamine-2 receptor antagonists.
- Main Outcome
- The rate of infections in neonates exposed or not to treatment with Histamine-2 receptor antagonist. Measures of effect Odds ratios.
- Outcome Measure
- Additional Outcome
- The occurrence of NEC, mortality, and hospital stays. Measures of effect Odds ratios.
- Study Method
- Intervention, Meta-analysis, Prognostic, Systematic review
- Keyword
- Enterocolitis, Necrotizing; Humans; Infant Health; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Perinatal Death; Ranitidine; Risk Factors; Treatment Outcome
- Contact
- Victor Santos [email protected]
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Completed published
- First Submission Date
- 2018-01-24
- Registration Date
- 2017-04-03
- Anticipated Start Date
- 2017-02-21
- Anticipated Completion Date
- 2017-06-30
- Title Cn
- 使用组胺-2受体拮抗剂是新生儿感染、坏死性小肠结肠炎和死亡的危险因素吗？
- Title En
- Is histamine-2 receptor antagonists use a risk factor for infection, necrotizing enterocolitis and mortality in neonates?
- Bilingual Status
- complete