Meta AnalysisID 269
药用真菌冬虫夏草联合ACEI/ARB对糖尿病肾脏疾病的影响：系统评价与Meta分析
CRD42022321043
The objective of this study was to evaluate the effects of medicinal fungi Cordyceps Sinensis combined with ACEI/ARB in the treatment of patients with diabetic kidney disease.
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Record Fields
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- Meta Analysis Id
- 269
- Evidence Id
- 8827
- Core Evidence Id
- 8827
- Source Meta Analysis Id
- 250
- Herb2 Meta Analysis Id
- HBMA000250
- Crd Id
- CRD42022321043
- Title
- The Effects of Medicinal Fungi Cordyceps Sinensis Combined with ACEI/ARB on Diabetic Kidney Disease： A Systematic Review and Meta-Analysis
- Review Question
- The objective of this study was to evaluate the effects of medicinal fungi Cordyceps Sinensis combined with ACEI/ARB in the treatment of patients with diabetic kidney disease.
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Diabetic kidney disease (DKD) was defined as the presence of microalbuminuria or macroalbuminuria in diabetic patients, occurs in 25% to 40% of patients with type 1 and 2 diabetes within 20 to 25 years after the onset of diabetes. As the global prevalence of diabetes continues to grow, it is estimated that the number of patients with DKD will double by 2025. About one-third of patients with DKD will develop end-stage renal disease (ESKD) and will require long-term dialysis, or possibly a kidney transplant. Symptoms of DKD are not obvious in stages I and II. Once DKD is in the end-stage (stage V), its treatment will be more difficult than other kidney diseases. Therefore, interventions to delay the progression of DKD and improve the condition become particularly important. Previous studies have identified two major classes of antihypertensive drugs, ACEIs and ARBs, that slow the progression of kidney disease by controlling albuminuria. Traditional Chinese Medicine (TCM) is one of the complementary and alternative treatments for DKD. Cordyceps Sinensis has been used for thousands of years as a traditional herbal medicine in China. Cordyceps Sinensis is a medicinal fungi complex parasitic on bat moth insect larvae and larval carcasses.
- Participant
- Inclusion: Patients were diagnosed with DKD according to the World Health Organization (WHO) diagnostic criteria, Mogensen staging criteria, and Kidney Disease: Improving Global Outcomes (KDIGO) diagnostic criteria. Excluded: Patients with primary renal disease, systemic infectious diseases, malignant tumors, and other severe organ dysfunction.
- Animal
- Human Disease Modelled
- Intervention
- Medicinal Fungi Cordyceps Sinensis (Jin Shui Bao Capsule, Xin Gan Bao Capsule, Ning Xin Bao Capsule, Bailing Capsule, Zhi Ling Capsule, Cordyceps Capsule) combined with ACEI/ARB.
- Comparator Control
- The control group received ACEI/ARB treatment for diabetic kidney disease.
- Main Outcome
- Critical Outcomes Composite renal endpoints: including the number of incidence of ESKD at the end of treatment or during follow-up; doubling of serum creatinine levels from baseline throughout the study period; kidney transplantation or death from renal failure; occurrence of cardiovascular events (heart failure attack, fatal myocardial infarction or non-fatal myocardial infarction, coronary artery disease confirmed by coronary angiography, sudden cardiac death). Measures of effect Meta-analyses of dichotomous outcomes and mean differences (MD) were performed using relative risk (RR), with 95% confidence intervals (CI).
- Outcome Measure
- Additional Outcome
- Important Outcomes ①Changes in urine protein of patients at the end of treatment, including 24-hour urine protein quantitative (24hUTP), urine albumin/creatinine ratio (ACR), urine albumin excretion rate (UAER), urine β2 microglobulin (β2-MG), Urinary albumin (UALB); ② Changes in renal function of patients at the end of treatment or during the follow-up period, including serum creatinine (Scr), blood urea nitrogen (BUN), glomerular filtration rate (eGFR), homocysteine (Hcy), cystatin C (CysC). Limited Importance Outcomes 1.4.2 General outcome measures ① Changes in blood pressure, blood lipids (triglyceride, cholesterol, lipoprotein), and blood sugar (fasting, postprandial) of patients at the end of treatment or during the follow-up period; ②Inflammatory factors (C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-18 (IL-18), tumor necrosis factor α (TNF-α), transforming growth factor β1 (TGF- β1)); ③ Oxidative stress indicators (malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS), advanced oxidation protein products (AOPPs)); ④ Safety results, the incidence of adverse reactions, and adverse reactions. Measures of effect Meta-analyses of dichotomous outcomes and mean differences (MD) were performed using relative risk (RR), with 95% confidence intervals (CI).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cordyceps; Diabetes Mellitus; Diabetic Nephropathies; Drug Therapy, Combination; Humans
- Contact
- Guanchi Yan [email protected]
- Organisational Affiliation
- Changchun University of Chinese Medicine（CCUCM）, College of Traditional Chinese Medicine https://www.ccucm.edu.cn
- Funding Source
- Natural Science Foundation of Jilin Province Science and Technology Development Plan(20200404045YY)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-28
- Registration Date
- 2022-04-28
- Anticipated Start Date
- 2022-04-15
- Anticipated Completion Date
- 2022-05-13
- Title Cn
- 药用真菌冬虫夏草联合ACEI/ARB对糖尿病肾脏疾病的影响：系统评价与Meta分析
- Title En
- The Effects of Medicinal Fungi Cordyceps Sinensis Combined with ACEI/ARB on Diabetic Kidney Disease： A Systematic Review and Meta-Analysis
- Bilingual Status
- complete