Meta AnalysisID 266
冬虫夏草及其提取物对糖尿病肾病动物模型的肾脏保护潜力：系统评价与Meta分析
CRD42020216415
to evaluate the specific efficacy of some cordyceps species including cordyceps millitaris, sinensis, cicadae and their extracts in relieving kidney damage in diabetes mellitus (DM) animal models.
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Record Fields
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- Meta Analysis Id
- 266
- Evidence Id
- 8824
- Core Evidence Id
- 8824
- Source Meta Analysis Id
- 247
- Herb2 Meta Analysis Id
- HBMA000247
- Crd Id
- CRD42020216415
- Title
- The reno-protective potential effect of Cordyceps and its extracts in diabetic nephropathy animal models—a systematic review and meta-analysis
- Review Question
- to evaluate the specific efficacy of some cordyceps species including cordyceps millitaris, sinensis, cicadae and their extracts in relieving kidney damage in diabetes mellitus (DM) animal models.
- Study Type Included
- select randomised trials to assess the beneficial effects of the treatments
- Condition Being Studied
- Diabetic nephropathy (DN) is a serious chronic microvascular complication of diabetes, and it has become one of the critical reason of ESRD and the most common cause of chronic kidney failure. Until now, the precise mechanism of diabetic kidney disease (DKD) is fragmentary and incomplete.Cordyceps species, being called as Dong-Chong-Xia-Cao in Chinese , are one of entomopathogenic fungi that belonging to Clavicipitaceae and Ascomycotina, which include various genera such as Cordyceps, Paecilomyces, Torrubiella and Podonectria. Among the cordyceps family, Cordyceps Sinensis (CS) and Cordyceps militaris (CM) as well as Cordyceps cicadae(CC) are commonly studied and widely used. C. sinensis is the critical restorative tonic in Chinese tradition, which can be comparable to the invigorants like Panax and Pilose antlers.
- Participant
- Diabetic animal model(DAM);The criteria of success animal model was fasting blood glucose (FBG)> 11.1 mmol/L or random blood GLU level ≥16.7 mmol/l.
- Animal
- Human Disease Modelled
- Intervention
- DAM was established in various ways;the experimental group received any dose of cordyceps species or their extracts only; and the control group was DN model with corresponding dose of nontherapeutic liquid just like citrate buffer、tap water and saline water.
- Comparator Control
- DN model /any dose of cordyceps species or their extracts
- Main Outcome
- serum creatinine (Scr), 24-hour urine protein(24-UTP) , blood urea nitrogen (BUN). Measures of effect RR、RD
- Outcome Measure
- Additional Outcome
- fasting blood glucose (FBG) , serum lipid level and interleukin-6(IL-6). Measures of effect RR、RD
- Study Method
- 介入, 荟萃分析, 临床前, 系统评价
- Keyword
- Animals; Cordyceps; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Plant Extracts
- Contact
- Yu Hua Jiang [email protected]
- Organisational Affiliation
- Beijing University of Chinese Medicine；The First Affiliated Hospital of Beijing University of traditional Chinese Medicine, Dongzhimen hospital
- Funding Source
- study was supported by the National Natural Science Foundation of China (grant nos. 81774278) Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> 81774278
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-11-30
- Registration Date
- 2020-12-30
- Anticipated Start Date
- 2020-10-01
- Anticipated Completion Date
- 2021-01-01
- Title Cn
- 冬虫夏草及其提取物对糖尿病肾病动物模型的肾脏保护潜力：系统评价与Meta分析
- Title En
- The reno-protective potential effect of Cordyceps and its extracts in diabetic nephropathy animal models—a systematic review and meta-analysis
- Bilingual Status
- complete