Meta AnalysisID 2646
肝素对比0.9%氯化钠间歇性冲洗预防婴幼儿与儿童长期中心静脉导管堵塞【Cochrane方案】
CRD42015017424
To assess the clinical effects (benefits and harms) of intermittent flushing of heparin versus 0.9% sodium chloride to prevent occlusion in long term central venous catheters (CVCs) in infants and children.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2646
- Evidence Id
- 11204
- Core Evidence Id
- 11204
- Source Meta Analysis Id
- 2598
- Herb2 Meta Analysis Id
- HBMA002598
- Crd Id
- CRD42015017424
- Title
- Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children [Cochrane Protocol]
- Review Question
- To assess the clinical effects (benefits and harms) of intermittent flushing of heparin versus 0.9% sodium chloride to prevent occlusion in long term central venous catheters (CVCs) in infants and children.
- Study Type Included
- We will include only randomised controlled trials. Due to potential bias, we will exclude studies that use alternative methods (quasi-randomised) to allocate participants to a control or intervention group.
- Condition Being Studied
- The Cochrane Peripheral Vascular Diseases Group
- Participant
- The study population comprises infants and children aged 1 to 18 years who have a CVC (tunnelled catheter or implanted port), inserted for long term venous access. Studies of infants or children with Midline catheters or PICCs are beyond the scope of this review and will be excluded. There are no restrictions on the insertion site, or catheter tip placement site (superior or inferior vena cava). There will be no restrictions on the healthcare setting in which the study has been conducted, e.g. tertiary hospital or community setting. Where studies have a mixed population that includes infants, children and adults, we will include data from infants and children only. If this information is not presented in the article, we will contact the study authors to attempt to obtain age-stratified results. If we are unable to contact the study authors, and children and infants comprise a proportion greater than 20% of the study population, we will include the appropriate threshold proportion. If we are unable to obtain any information regarding the proportion of infants and children in the study population, we will exclude the study from the review.
- Animal
- Human Disease Modelled
- Intervention
- The intervention of interest is the intermittent (any time frequency) flushing of heparin (any dose or concentration) compared with intermittent flushing with 0.9% sodium chloride solution (alone, or in combination with pulsatile flushing techniques, positive displacement devices or positive pressure lock) delivered with the intention to prevent occlusion of the CVC.
- Comparator Control
- Intermittent flushing with 0.9% sodium chloride solution (alone, or in combination with pulsatile flushing techniques, positive displacement devices or positive pressure lock).
- Main Outcome
- Occlusion of the CVC, determined by the inability to infuse fluids through the catheter Duration in weeks of catheter placement Any adverse event associated with CVCs (catheter-related thrombosis, sepsis, central line associated blood stream infection (CLABSI) or colonisation of the catheter, allergic reaction, haemorrhage, heparin-induced thrombocytopaenia (HIT), elevated hepatic enzymes)</ul> Outcomes will not be considered a part of eligibility criteria.
- Outcome Measure
- Additional Outcome
- Ability to withdraw blood from the CVC Any use of urokinase or recombinant tissue plasminogen such as alteplase Incidence of removal and re-insertion of the catheter </ul>
- Study Method
- Keyword
- Anticoagulants; Catheterization, Central Venous; Central Venous Catheters; Child; Heparin; Humans; Infant; Sodium Chloride
- Contact
- Natalie K Bradford [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- The University of Queensland''s Centre for Online Health, Chief Scientist Office, Scottish Government Health Directorates, The Scottish Government, Royal Children''s Hospital, Queensland, Royal Brisbane and Women''s Hospital, Queensland
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2015-03-09
- Anticipated Start Date
- 2014-02-15
- Anticipated Completion Date
- 2016-02-15
- Title Cn
- 肝素对比0.9%氯化钠间歇性冲洗预防婴幼儿与儿童长期中心静脉导管堵塞【Cochrane方案】
- Title En
- Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children [Cochrane Protocol]
- Bilingual Status
- complete