Meta AnalysisID 2617
支架辅助弹簧圈栓塞颅内动脉瘤术中使用糖蛋白IIb/IIIa抑制剂的安全性和有效性：系统评价与Meta分析
CRD42020168536
1. to evaluate the safty and efficacy (e.g. thromboembolic events, hemorrhage, mortality, recanalization)that Glycoprotein IIb/IIIa Inhibitors were used during stent-assisted coiling of intracranial aneurysm. 2. to evalu
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Record Fields
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- Meta Analysis Id
- 2617
- Evidence Id
- 11175
- Core Evidence Id
- 11175
- Source Meta Analysis Id
- 2569
- Herb2 Meta Analysis Id
- HBMA002569
- Crd Id
- CRD42020168536
- Title
- Systematic review and meta-analysis of the safety and efficacy of Glycoprotein IIb/IIIa Inhibitors using during stent-assisted coiling of intracranial aneurysm
- Review Question
- 1. to evaluate the safty and efficacy (e.g. thromboembolic events, hemorrhage, mortality, recanalization)that Glycoprotein IIb/IIIa Inhibitors were used during stent-assisted coiling of intracranial aneurysm. 2. to evaluate the difference of the safty and efficacy among the three kinds of Inhibitors( tirofiban, eptifibatide, abciximab)
- Study Type Included
- inclusion criteria -available full-text of case-controlled trial, cohort trial and single arm clinical trial -studies reported more than 5 cases of intracranial aneurysm undergoing the treatment of stent-assisted coiling -studies reported detailed description periprocedural complications and procedure-related mortality at least
- Condition Being Studied
- Stent-assisted coiling is one of the main treatment for intracranial aneurysm.However poor prognosis, even higher mortality may be caused by the complications that includes thromboembolic events and hemorrhage in process of endovascular treatment. For purpose of preventing these complications and treating thromboembolism, Glycoprotein IIb/IIIa inhibitors were attempted experiencely during stent-assisted coiling for ruptured and unruptured intracranial aneurysm. Up to now, related systematic review and meta-analysis concerning the safty and efficacy of Glycoprotein IIb/IIIa inhibitors during stent-assisted coiling is rarely.This review aims to evaluate the safty and efficacy by summarizing existing literatures and offer reasonable guidance for clinicians to handle with complications and lower the occurrence.
- Participant
- Inclusion criteria: -the patients with intracranial aneurysm undergoing the treatment of stent-assisted coiling
- Animal
- Human Disease Modelled
- Intervention
- Using glycoprotein IIb/IIIa inhibitors（tirofiban, eptifibatide or abciximab） in the perioperative period
- Comparator Control
- oral antiplatelet therapy, different glycoprotein IIb/IIIa inhibitors
- Main Outcome
- Prophylactic use of glycoprotein IIb/IIIa inhibitors 1.the overall incidence of complications (thromboembolic events and hemorrhage) hemorrhage includes intracranial hemorrhage and gastrointestinal hemorrhage 2.the respective incidence of complications (thromboembolic events and hemorrhage) among three different glycoprotein IIb/IIIa inhibitors 3.death rate Therapeutic use of glycoprotein IIb/IIIa inhibitors for Thromboembolism 1.rates of success in terms of recanalization (defined as III or IIB according to TICI grade) 2.the overall incidence of hemorrhage and death 3.the respective incidence of hemorrhage and death among three different glycoprotein IIb/IIIa inhibitors Measures of effect 1.the complications (thromboembolic events and hemorrhage) and death rate would be included by the time of discharge2.if the data allows, the odd ratios (ORs) of complications (thromboembolic events, hemorrhage and death rate) would be calculated to compare glycoprotein IIb/IIIa inhibitors and oral antiplatelet therapy in prophylactic use.
- Outcome Measure
- Additional Outcome
- Prophylactic use of glycoprotein IIb/IIIa inhibitors 1.GOS（Glasgow outcome scale）or mRS（modified rankin scale） at discharge and follow-up period Good prognosis：GOS more than 3 or mRS less than 3 2.the overall incidence of delayed thromboembolic events if the data allows，the respective incidence rates would be calculated. delayed thromboembolic events：thromboembolic events occured during the follow-up period Therapeutic use of glycoprotein IIb/IIIa inhibitors for Thromboembolism 1.the overall incidence of distal embolism after recanalization distal embolism：distal artery occlusion owing to thrombus formed in parent artery during procedures 2.GOS（Glasgow outcome scale）or mRS（modified rankin scale） at discharge and follow-up period Good prognosis：GOS more than 3 or mRS less than 3 Measures of effect if the data allows, the odd ratios (ORs) of delayed thromboembolic events would be calculated to compare lycoprotein IIb/IIIa inhibitors and oral antiplatelet therapy in prophylactic use.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Aneurysm, Ruptured; Embolization, Therapeutic; Glycoproteins; Humans; Intracranial Aneurysm; Stents
- Contact
- Wentao Gong [email protected]
- Organisational Affiliation
- the Affiliated Hosipital of Qingdao University
- Funding Source
- No funding sources and sponsors
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-02-12
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-02-06
- Anticipated Completion Date
- 2020-05-31
- Title Cn
- 支架辅助弹簧圈栓塞颅内动脉瘤术中使用糖蛋白IIb/IIIa抑制剂的安全性和有效性：系统评价与Meta分析
- Title En
- Systematic review and meta-analysis of the safety and efficacy of Glycoprotein IIb/IIIa Inhibitors using during stent-assisted coiling of intracranial aneurysm
- Bilingual Status
- complete