Meta AnalysisID 2613
聚乙二醇电解质溶液与乳果糖治疗肝性脑病的疗效与安全性：随机对照试验的系统评价与Meta分析
CRD42021245648
P: patients of hepatic encephalopathy I: polyethylene glycol(PEG) electrolyte solution C:lactulose O:Improvement of HE; the lengty of hospital stay; adverse effects; the level of serum ammonia S:RCT
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2613
- Evidence Id
- 11171
- Core Evidence Id
- 11171
- Source Meta Analysis Id
- 2565
- Herb2 Meta Analysis Id
- HBMA002565
- Crd Id
- CRD42021245648
- Title
- The efficacy and safety of polyethylene glycol electrolyte solution(PEG) versus lactulose for hepatic encephalopathy: a systematic review and meta-analysis of randomized controlled trial
- Review Question
- P: patients of hepatic encephalopathy I: polyethylene glycol(PEG) electrolyte solution C:lactulose O:Improvement of HE; the lengty of hospital stay; adverse effects; the level of serum ammonia S:RCT
- Study Type Included
- RCT
- Condition Being Studied
- Hepatic encephalopathy is a complex neuropsychiatric syndrome, which may complicate acute or chronic liver failure. It is characterized by changes in mental state including a wide range of neuropsychiatric symptoms ranging from minor signs of altered brain function to deep coma.
- Participant
- Patients having all the following criteria were included: Documented cirrhosis with any underlying etiology Hepatic encephalopathy of any grade 18 to 80 years of age Exclusion criteria were as follows: Acute liver failure defined as severe acute liver injury with encephalopathy and international normalized ratio (INR)≥1.5 in a patient without pre-existing liver disease Acute change in mental status due to a diagnosis other than hepatic encephalopathy Hemodynamic instability obviating vasopressors for resuscitation Pregnancy Lack of legally authorized representatives (LARs) Refusal of consent by the LARs Patient’s unwillingness to participate
- Animal
- Human Disease Modelled
- Intervention
- polyethylene glycol electrolyte solution (PEG)
- Comparator Control
- lactulose
- Main Outcome
- Improvement of hepatic encephalopathy which defined as at least one scale improvement in HESA score Measures of effect relative risks
- Outcome Measure
- Additional Outcome
- Adverse effect; Lengty of hospital stay; Level of serum ammonia Measures of effect relative risks;Mean Deviation
- Study Method
- Systematic review
- Keyword
- Constipation; Electrolytes; Hepatic Encephalopathy; Humans; Lactulose; Polyethylene Glycols; Randomized Controlled Trials as Topic
- Contact
- Mengting Li [email protected]
- Organisational Affiliation
- guangxi medical university
- Funding Source
- This research received no specific funding/grant from any funding agency in the public, commercial, or not for profit sectors.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-03-28
- Registration Date
- 2021-04-28
- Anticipated Start Date
- 2021-03-01
- Anticipated Completion Date
- 2021-06-30
- Title Cn
- 聚乙二醇电解质溶液与乳果糖治疗肝性脑病的疗效与安全性：随机对照试验的系统评价与Meta分析
- Title En
- The efficacy and safety of polyethylene glycol electrolyte solution(PEG) versus lactulose for hepatic encephalopathy: a systematic review and meta-analysis of randomized controlled trial
- Bilingual Status
- complete