Meta AnalysisID 2608
24个月以下儿童便秘的聚乙二醇给药：一项系统评价
CRD42018104593
What is the most appropriate treatment regimen for polyethylene glycol (PEG) in children less than two years of age?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2608
- Evidence Id
- 11166
- Core Evidence Id
- 11166
- Source Meta Analysis Id
- 2558
- Herb2 Meta Analysis Id
- HBMA002558
- Crd Id
- CRD42018104593
- Title
- Polyethylene Glycol Dosing for Constipation in Children Younger Than 24 Months: A Systematic Review
- Review Question
- What is the most appropriate treatment regimen for polyethylene glycol (PEG) in children less than two years of age?
- Study Type Included
- We will include randomised control trials to asses the effectiveness and safety of PEG treatment of functional constipation of children less than 24 months of age, compared to alternative forms of treatment. This will be supplemented by retrospective chart reviews to assess safety, effectiveness and optimal dosage of PEG in the treatment of functional constipation in children less than 24 months of age.
- Condition Being Studied
- Functional constipation in children under 24 months of age.
- Participant
- Inclusion criteria: children less than 24 months of age; PEG therapy used to treat functional constipation; dosage, safety, and the efficacy of PEG discussed. Exclusion criteria: no specific age group stated, or participants less than 24 months of age; organic causes of constipation; PEG type used not specified.
- Animal
- Human Disease Modelled
- Intervention
- Polyethylene glycol (PEG) treatments, including (the number indicating the average molecular weight of each type of PEG): PEG3350 with electrolytes; PEG3350 without electrolytes; PEG4000 with electrolytes; PEG4000 without electrolytes.
- Comparator Control
- As this systematic review seeks to evaluate the effectiveness, safety and optimal dosage of PEG treatment of functional constipation, the various forms of PEG treatment, as well as whether the PEG treatment is with or without electrolytes, will serve as comparators for the other groups of treatment. Any randomised controlled trials included in this systematic review are likely to use two different types or dosages of Polyethylene Glycol as the two arms of the study, to identify superior effectiveness, rather than controls. In some studies, participants may have also served as their own controls, before being put onto PEG treatment.
- Main Outcome
- Changes in symptoms related to functional constipation, including, but not limited to: abdominal pain, frequency of diarrhoea, volume of diarrhoea, flatulence, irritability/crying during bowel movement; and redness/inflammation due to straining while having a bowel movement. Measures of effect The times at which these measurements are made is expected to vary slightly between each individual study, but would be expected to occur in the weeks/months after commencing regular PEG treatment.
- Outcome Measure
- Additional Outcome
- Additional outcomes that will be recorded included the occurrence of any adverse effects following PEG treatment, lack of compliance of participants and dissatisfaction of treatment by participants or their families. Measures of effect The times at which these measurements are made is expected to vary slightly between each individual study, but would be expected to occur in the weeks/months after commencing regular PEG treatment.
- Study Method
- Intervention, Systematic review
- Keyword
- Cathartics; Constipation; Defecation; Humans; Infant; Infant Health; Polyethylene Glycols; Treatment Outcome
- Contact
- Andrew Griffith [email protected]
- Organisational Affiliation
- University of Melbourne https://www.unimelb.edu.au/
- Funding Source
- Other Selection Criteria
- Final Publication
- Published in the Journal of Pediatric Gastroenterology and Nutrition in August 2020. doi: 10.1097/MPG.0000000000002786. https://journals.lww.com/jpgn/Abstract/2020/08000/Polyethylene_Glycol_Dosing_for_Constipation_in.9.aspx
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Country
- Australia
- Review Stage
- Review Completed published
- First Submission Date
- 2018-09-11
- Registration Date
- 2018-10-10
- Anticipated Start Date
- 2017-09-01
- Anticipated Completion Date
- 2018-12-21
- Title Cn
- 24个月以下儿童便秘的聚乙二醇给药：一项系统评价
- Title En
- Polyethylene Glycol Dosing for Constipation in Children Younger Than 24 Months: A Systematic Review
- Bilingual Status
- complete