Meta AnalysisID 2606
烧伤患者局部抗菌药物中乙二醇载体的毒性
CRD42016048459
What is the rate of systemic acidotic hyperosmolar toxicity among burn patients who were treated with topical glycol based antimicrobial creams and ointments
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Record Fields
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- Meta Analysis Id
- 2606
- Evidence Id
- 11164
- Core Evidence Id
- 11164
- Source Meta Analysis Id
- 2556
- Herb2 Meta Analysis Id
- HBMA002556
- Crd Id
- CRD42016048459
- Title
- Toxicity of glycol vehicles in topically applied antimicrobial agents for burn patients
- Review Question
- What is the rate of systemic acidotic hyperosmolar toxicity among burn patients who were treated with topical glycol based antimicrobial creams and ointments
- Study Type Included
- Study types to be included: retrospective chart review, any RCT, any cohort study, any case control and any observational study. We did not look for case reports and case series.
- Condition Being Studied
- The condition is the appearance of sudden systemic toxicity in a burn patient treated with a topical antimicrobial agent. Most patients suffering this unusual adverse effect are classified as septic due to acidosis and sudden clinical change. further complications include hyperosmolarity, seizures and death.
- Participant
- All burn (fire and heat, chemical and electricity) victims will be included, as long as the medical team decided not to preform invasive procedures (skin grafting etc..) and opted for topical antimicrobial treatment. And provided that the paper provides clear complication and mortality data
- Animal
- Human Disease Modelled
- Intervention
- All topical agents (creams, ointments etc...) that have a glycol molecule (Polyethylene glycol and/or Propylene glycol) as apart of their vehicle will be included, provided that the paper states that they were used for infection control on burn areas. We won't include invasive / surgical procedures or any medication the was prescribed for indication other than burn wound infection.
- Comparator Control
- Main Outcome
- Rate of the reported following complications: acidosis, hyperosmolarity, seizures. blood / urine / other tissue tests confirming that the patient suffered / succumbed to (any) glycol toxicity. Measures of effect The first 3 weeks after admission to the burn unit are critical. Most responses develop within a few days.
- Outcome Measure
- Additional Outcome
- Rate of septic episodes with and without positive culture. Mortality rate. Measures of effect The first 3 weeks after admission to the burn unit are critical. Most adverse reactions develop within a few days.
- Study Method
- Systematic review
- Keyword
- Anti-Infective Agents; Burns; Glycols; Humans
- Contact
- Tom Leibson [email protected]
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2016-09-27
- Anticipated Start Date
- 2016-07-01
- Anticipated Completion Date
- 2016-12-31
- Title Cn
- 烧伤患者局部抗菌药物中乙二醇载体的毒性
- Title En
- Toxicity of glycol vehicles in topically applied antimicrobial agents for burn patients
- Bilingual Status
- complete