Meta AnalysisID 2605
谷胱甘肽S-转移酶基因多态性与肝硬化风险关联的Meta分析
CRD42020185587
Is there any association between the glutathione S-transferase (GSTM1, GSTT1, and GSTP1) polymorphisms and the risk of liver cirrhosis?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2605
- Evidence Id
- 11163
- Core Evidence Id
- 11163
- Source Meta Analysis Id
- 2555
- Herb2 Meta Analysis Id
- HBMA002555
- Crd Id
- CRD42020185587
- Title
- A meta-analysis of the association between glutathione S-transferase gene polymorphisms and the risk of liver cirrhosis
- Review Question
- Is there any association between the glutathione S-transferase (GSTM1, GSTT1, and GSTP1) polymorphisms and the risk of liver cirrhosis?
- Study Type Included
- case-control, cohort, nested case-control
- Condition Being Studied
- Cirrhosis is characterized by fibrosis and nodule formation of the liver, secondary to a chronic injury, which leads to alteration of the normal lobular organization of the liver. Cirrhosis is currently the 11th most common cause of death globally and liver cancer is the 16th leading cause of death; combined, they account for 3.5% of all deaths worldwide. Despite the tremendous amount of progress in our understanding of the etiology of liver cirrhosis, worth considering cases are cryptogenic, i.e. cirrhosis of the liver of undetermined etiology. This is true especially in Sub Saharan Africa, where hepatitis B virus (HBV), hepatitis C virus (HCV), and alcohol consumption are involved in 34%, 17%, and 18% of cases as an etiologic factor. However, in 31% of cases, the etiology is unknown, according to a recent global burden of disease report. It is, therefore, our review aims to assess any association between the glutathione S-transferase (GSTM1, GSTT1, and GSTP1) polymorphisms and the risk of liver cirrhosis.
- Participant
- Adults (> 18 years) with liver cirrhosis
- Animal
- Human Disease Modelled
- Intervention
- Glutathione S-transferase (GSTM1, GSTT1, and GSTP1) polymorphisms
- Comparator Control
- Unrelated healthy adult male or female subjects without liver cirrhosis
- Main Outcome
- Odds ratio or risk ratio of association between liver cirrhosis and Glutathione S-transferase (GSTM1, GSTT1, and GSTP1) Measures of effect odds ratios
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Glutathione Transferase; Humans; Liver Cirrhosis; Polymorphism, Genetic
- Contact
- Abraham Nigussie Mekuria [email protected]
- Organisational Affiliation
- Haramaya University
- Funding Source
- No funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Ethiopia
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-05-17
- Registration Date
- 2020-07-05
- Anticipated Start Date
- 2020-05-20
- Anticipated Completion Date
- 2020-09-17
- Title Cn
- 谷胱甘肽S-转移酶基因多态性与肝硬化风险关联的Meta分析
- Title En
- A meta-analysis of the association between glutathione S-transferase gene polymorphisms and the risk of liver cirrhosis
- Bilingual Status
- complete