Meta AnalysisID 2604
谷胱甘肽治疗动物自闭症谱系障碍相关行为的有效性与安全性
CRD42019122983
What are the evidence for effectiveness and safety of glutathione in treating Autism Spectrum Disorder-relevant behavioral phenotypes in animal studies Context and rationale We aim to summarize the benefits and harms of
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Record Fields
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- Meta Analysis Id
- 2604
- Evidence Id
- 11162
- Core Evidence Id
- 11162
- Source Meta Analysis Id
- 2554
- Herb2 Meta Analysis Id
- HBMA002554
- Crd Id
- CRD42019122983
- Title
- The effectiveness and safety of glutathione in treating Autism Spectrum Disorder-relevant behaviors in animals
- Review Question
- What are the evidence for effectiveness and safety of glutathione in treating Autism Spectrum Disorder-relevant behavioral phenotypes in animal studies Context and rationale We aim to summarize the benefits and harms of treating autism spectrum disorder with glutathione. We expect there will be little evidence for glutathione in human studies (See the corresponding PROSPERO human review]). We plan to search for evidence of the effects of glutathione in animal models of autism spectrum disorder. We plan to use the findings from the animal model review to supplement our review on human studies.
- Study Type Included
- Inclusion criteria: All study designs are eligible Exclusion criteria: No exclusion criteria
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: In vivo studies of animal models of Autism Spectrum Disorder or animal behavioral phenotypes potentially relevant to Autism Spectrum Disorder core symptoms Exclusion criteria: ex vivo studies, in vitro studies, studies in humans or in sillico studies
- Human Disease Modelled
- Autism Spectrum Disorder
- Intervention
- Inclusion criteria: Administration of glutathione Exclusion criteria: Unable to isolate the effects of glutathione
- Comparator Control
- Inclusion criteria: Information on any comparison/control group of a study will be included Exclusion criteria: No exclusion criteria
- Main Outcome
- Outcome Measure
- Inclusion criteria: Effectiveness outcomes using predefined list of animal behavior tests. Safety outcomes include any adverse or side effects reported in the studies. Exclusion criteria: We will exclude studies that do not report on either an outcome related to a core symptom of autism spectrum disorder or a safety outcome.
- Additional Outcome
- Study Method
- Keyword
- Animals; Autism Spectrum Disorder; Glutathione
- Contact
- Vadim Dukhanin [email protected]
- Organisational Affiliation
- Johns Hopkins University
- Funding Source
- U.S. Food and Drug Administration (FDA)
- Other Selection Criteria
- Only articles with original data excluding commentaries, reviews, and protocols of trials. Conference abstracts are included.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-01-22
- Registration Date
- 2019-04-17
- Anticipated Start Date
- 2018-11-01
- Anticipated Completion Date
- 2019-08-31
- Title Cn
- 谷胱甘肽治疗动物自闭症谱系障碍相关行为的有效性与安全性
- Title En
- The effectiveness and safety of glutathione in treating Autism Spectrum Disorder-relevant behaviors in animals
- Bilingual Status
- complete