Meta AnalysisID 2561
乳酸发酵食品对成人糖尿病患者血糖控制的影响：随机对照试验的系统评价与Meta分析
CRD42022295220
Effectiveness of lactic acid fermented foods on glycaemic control in diabetic adults.
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Record Fields
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- Meta Analysis Id
- 2561
- Evidence Id
- 11119
- Core Evidence Id
- 11119
- Source Meta Analysis Id
- 2509
- Herb2 Meta Analysis Id
- HBMA002509
- Crd Id
- CRD42022295220
- Title
- Effect of lactic acid fermented foods on glycaemic control in diabetic adults: A Systemic Review and Meta-Analysis of Randomised Controlled Trials
- Review Question
- Effectiveness of lactic acid fermented foods on glycaemic control in diabetic adults.
- Study Type Included
- Randomised controlled trials (RCTs) Inclusion criteria: Randomised crossover study, randomized, double-blind, parallel-group, placebo-controlled trial. Exclusion criteria: Reviews, meta-analysis, qualitative study, non-experimental design studies.
- Condition Being Studied
- Diabetes mellitus is a chronic metabolic disorder, in which the body cannot respond to insulin effectively or there is insufficient insulin production from the pancreas, causing abnormally high blood glucose levels or hyperglycaemia. Type 2 diabetes mellitus (T2DM) is characterised by insulin resistance, where the body does not respond to insulin effectively. Prediabetes is a condition of intermediate hyperglycaemia but with blood glucose levels below the T2DM diagnostic threshold.
- Participant
- Inclusion criteria: Adults with type 2 diabetes mellitus or prediabetes (as diagnosed using any recognised diagnostic criteria). Exclusion criteria: Type 1 diabetes or gestational diabetes or studies involving adolescents (under 18 years of age) or animals (mice or rat).
- Animal
- Human Disease Modelled
- Intervention
- Intervention: Lactic acid bacteria (LAB) fermented foods, that undergo anaerobic process where sugars, such as glucose, into lactic acid, lactate, and other products. Inclusion criteria: Fermented foods include yoghurt, kefir, sauerkraut, kimchi and cheonggukjang, sourdough, kombucha, miso and natto, et cetera. Exclusion criteria: Foods that did not undergo fermentation, probiotic supplements.
- Comparator Control
- Placebo/control Inclusion criteria: non-exposed control group.
- Main Outcome
- Most important - Glycosylated Haemoglobin (HbA1c): An ideal glycaemic control HbA1c goal is levels below 7% (53 mmol/mol) without significant hypoglycaemia. Fasting plasma glucose (FPG) test uses enzymatic methods such as glucose oxidase and hexokinase. It measures the glucose levels in your blood after at least 8 hours of fasting. The ideal normal FPG range is considered to be 70-99mg/dL, with 100-125mg/dL indicating prediabetes and above 126mg/dL as type 2 diabetes mellitus. Fasting serum insulin is a test used to measure the amount of insulin in the body. It measures the insulin levels in your blood after at least 8 hours of fasting. The normal range is <25mIU/L (<174pmol/L). Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) assesses the function of beta-cell by calculating the fasting glucose and insulin concentrations levels. The normal HOMA-IR level is 1 and the higher the HOMA-IR value, the more resistant the individual is to insulin.
- Outcome Measure
- Additional Outcome
- Lipid profile such as low-density lipoproteins (LDL), high-density lipoproteins (HDL), Triglycerides (TG), Total Cholesterol (TC) and inflammatory markers such as Interleukin 6 (IL-6) and tumour necrosis factor alpha (TNF-a). Other markers such as systolic blood pressure (SBP), diastolic blood pressure (DBP) and body mass index (BMI).
- Study Method
- Intervention, Meta-analysis, Prevention, Systematic review
- Keyword
- Adult; Diabetes Mellitus; Fermented Foods; Glycemic Control; Humans; Lactic Acid
- Contact
- Teo Wei Zhou [email protected]
- Organisational Affiliation
- National University of Singapore https://www.nus.edu.sg/
- Funding Source
- Other Selection Criteria
- Final Publication
- Teo WZ, See JY, Ramazanu S, Chan JCY, Wu XV. Effect of lactic acid fermented foods on glycemic control in diabetic adults: a systemic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022 Sep 30:1-16. doi: 10.1080/10408398.2022.2128032. https://doi.org/10.1080/10408398.2022.2128032
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Singapore
- Review Stage
- Review Completed published
- First Submission Date
- 2021-12-13
- Registration Date
- 2022-01-12
- Anticipated Start Date
- 2021-08-19
- Anticipated Completion Date
- 2022-03-04
- Title Cn
- 乳酸发酵食品对成人糖尿病患者血糖控制的影响：随机对照试验的系统评价与Meta分析
- Title En
- Effect of lactic acid fermented foods on glycaemic control in diabetic adults: A Systemic Review and Meta-Analysis of Randomised Controlled Trials
- Bilingual Status
- complete