Meta AnalysisID 2553
氨基葡萄糖联合药物干预治疗膝骨关节炎的相对有效性：随机对照试验的网状Meta分析
CRD42022331863
To compare the relative effectiveness of glucosamine in combination with different pharmacological interventions for pain in patients with knee osteoarthritis.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2553
- Evidence Id
- 11111
- Core Evidence Id
- 11111
- Source Meta Analysis Id
- 2501
- Herb2 Meta Analysis Id
- HBMA002501
- Crd Id
- CRD42022331863
- Title
- Relative effectiveness of glucosamine combined with pharmacological interventions for knee osteoarthritis: A network meta-analysis of randomized controlled trials
- Review Question
- To compare the relative effectiveness of glucosamine in combination with different pharmacological interventions for pain in patients with knee osteoarthritis.
- Study Type Included
- Randomized controlled trials (RCTs).
- Condition Being Studied
- Knee osteoarthritis (KOA) is a common chronic disorder of the knee and the leading cause of pain in the elderly. Glucosamine in combination with various pharmacological interventions has been widely used to treat KOA, including chondroitin sulfate, hyaluronic acid, methyl-sulfonyl-methane, celecoxib, etoricoxib, and other active compounds. However, the efficacy and safety of these combined therapies have not been systematically compared and assessed. In addition, conventional pairwise meta-analyses can only compare two treatments at a time, and only through network meta-analysis (NMA) can we examine all available combined interventions simultaneously in a single analysis. Because NMA can combine direct and indirect evidence, it can assess the relative effectiveness of the different combination interventions. To date, no previous NMA has examined these pharmacological interventions with glucosamine. Therefore, we will perform the NMA to compare the effectiveness of glucosamine in combination with pharmacological interventions in KOA.
- Participant
- Knee osteoarthritis patients
- Animal
- Human Disease Modelled
- Intervention
- Glucosamine (oral dosage form) in combination with different pharmacological interventions.
- Comparator Control
- Any of the described interventions compare with each other, placebo, glucosamine alone, or another active comparator.
- Main Outcome
- Pain intensity, as measured using the visual analogue scale (VAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale, numeric rating scale (NRS), or other pain reported scale. Measures of effect The pooled odds ratios (OR) with 95% confidence interval are calculated for dichotomous data. Mean difference (MD) or standardized mean difference (SMD) with 95% confidence interval are calculated for continuous data.
- Outcome Measure
- Additional Outcome
- Health-related quality of life and adverse events.
- Study Method
- Intervention, Network meta-analysis, Systematic review
- Keyword
- Glucosamine; Humans; Network Meta-Analysis; Osteoarthritis, Knee; Randomized Controlled Trials as Topic; Treatment Outcome
- Contact
- Yonggeun Hong [email protected]
- Organisational Affiliation
- 1. Department of Physical Therapy, College of Healthcare Medical Science & Engineering, Inje University, Republic of Korea 2. Institute of Senior Life Redesign, Inje University, Republic of Korea 3. Biohealth Products Research Center (BPRC), Inje University, Republic of Korea 4. Department of Rehabilitation Science, Graduate School of Inje University, Republic of Korea https://www.inje.ac.kr/
- Funding Source
- National Research Foundation, Korea. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> NRF-2020R1A2C201215512 to YH
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- South Korea
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-11
- Registration Date
- 2022-05-22
- Anticipated Start Date
- 2022-04-04
- Anticipated Completion Date
- 2022-08-30
- Title Cn
- 氨基葡萄糖联合药物干预治疗膝骨关节炎的相对有效性：随机对照试验的网状Meta分析
- Title En
- Relative effectiveness of glucosamine combined with pharmacological interventions for knee osteoarthritis: A network meta-analysis of randomized controlled trials
- Bilingual Status
- complete