Meta AnalysisID 2550
确定氨基葡萄糖和软骨素联合用药对膝骨关节炎患者的影响：一项系统评价和Meta分析
CRD42020202093
Is the treatment of the combination of glucosamine and chondroitin effective for patients with knee osteoarthritis (OA), in terms of pain relief and function recovery? Is the combination of glucosamine and chondroitin a
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2550
- Evidence Id
- 11108
- Core Evidence Id
- 11108
- Source Meta Analysis Id
- 2498
- Herb2 Meta Analysis Id
- HBMA002498
- Crd Id
- CRD42020202093
- Title
- Identify the effects of the combination of glucosamine and chondroitin in patients with knee osteoarthritis: a systematic review and meta-analysis
- Review Question
- Is the treatment of the combination of glucosamine and chondroitin effective for patients with knee osteoarthritis (OA), in terms of pain relief and function recovery? Is the combination of glucosamine and chondroitin a better choice, comparing to NSAIDs?
- Study Type Included
- Only randomized clinical trials (RCTs) will be included.
- Condition Being Studied
- Patients with knee osteoarthritis. Pain relief and function recovery of knee.
- Participant
- Inclusion: Adults with knee osteoarthritis who meet the diagnostic criteria of American College of Rheumatology (ACR) or Chinese Rheumatology Association (CRA). No restrictions for gender, age and severity of knee osteoarthritis. Exclusion: Patients with mental disease or other chronic diseases, or injuries or diseases of knee.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: Studies that investigated the effects of oral administration of the combination of glucosamine and chondroitin among patients with OA, diagnosed through the diagnostic criteria of ACR or CRA. Exclusion: Studies using diagnostic tool other than ACR/CRA diagnostic criteria; Studies in which patients were receiving other interventions like physiotherapy, anti-inflammatory drugs and so on.
- Comparator Control
- Inclusion: Studies that include using one drug alone or Nonsteroidal Antiinflammatory Drugs (NSAIDs), or placebos which are totally same with glucosamine or chondroitin in shape, smell and package. Exclusion: Studies with no control group.
- Main Outcome
- Overall improvement and pain improvement. Measures of effect The overall improvement will be measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Pain will be measured by the Visual Analogue Scale (VAS). The effect sizes will be expressed as Mean Differences (MDs).
- Outcome Measure
- Additional Outcome
- Detail improvement in function, pain and stiffness. The progression of knee degeneration. And the adverse effect. Measures of effect Improvement in function, pain and stiffness will be measured by three subscales of WOMAC, WOMAC function, WOMAC pain and WOMAC stiffness respectively. The progression of knee degeneration will be measured by the radiology manifestation as Joint Space Narrowing (JSN). The effect sizes of all above will be expressed as Mean Differences (MDs). The adverse effect (AE) will be measured by the rate of adverse events. The effect sizes of AE will be expressed as Relative Risks (RR).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Chondroitin; Glucosamine; Humans; Osteoarthritis, Knee
- Contact
- Zhengyuan Meng [email protected]
- Organisational Affiliation
- Medical College of Zhengzhou University http://www7.zzu.edu.cn/smzzu/index.htm
- Funding Source
- No funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Chinese-Simplified, English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-10-27
- Registration Date
- 2020-11-27
- Anticipated Start Date
- 2020-10-20
- Anticipated Completion Date
- 2020-11-30
- Title Cn
- 确定氨基葡萄糖和软骨素联合用药对膝骨关节炎患者的影响：一项系统评价和Meta分析
- Title En
- Identify the effects of the combination of glucosamine and chondroitin in patients with knee osteoarthritis: a systematic review and meta-analysis
- Bilingual Status
- complete