Meta AnalysisID 2541
人参皂苷Rg1抗2型糖尿病肠病的临床前证据：一项Meta分析和系统评价
CRD42023386830
To explore the evidence for the effectiveness of Ginsenoside Rg1 for modifing Type 2 Diabetes Mellitus and its complications
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Record Fields
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- Meta Analysis Id
- 2541
- Evidence Id
- 11099
- Core Evidence Id
- 11099
- Source Meta Analysis Id
- 2489
- Herb2 Meta Analysis Id
- HBMA002489
- Crd Id
- CRD42023386830
- Title
- Preclinical evidence for Ginsenoside Rg1 against Type 2 Diabetes Mellitus bowel disease: a meta‑analysis and systematic review
- Review Question
- To explore the evidence for the effectiveness of Ginsenoside Rg1 for modifing Type 2 Diabetes Mellitus and its complications
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Ginsenoside Rg1 constitutes the most active, as well as abundant steroid saponin among these saponins , exhibiting a diverse range of biological and pharmacological activities, such as anti-oxidation, anti-aging, anti-inflammation, and anti-diabetes. Meanwhile, it is a protopanaxatriol-type ginsenoside with different glycosyl groups in C-3/C-6 and C-20 positions, which can eliminate glycosyl groups of C-20 and C-6 during metabolism . Although a recent study demonstrated that ginsenoside Rg1 could have a potential therapeutic effect on T2D , its relationship with T2D and the intestinal microbiota remains unknown. Therefore, our research aims to determine the efficacy of ginsenoside Rg1 supplementation in ameliorating T2D in Sprague Dawley (SD) rats fed a HFD, as well as the relationship between ginsenoside Rg1 and T2D-linked parameters and the intestinal microflora.
- Participant
- the T2D rats
- Animal
- Human Disease Modelled
- Intervention
- With a certain dosage of ginsenoside Rg1
- Comparator Control
- With other basic treatments
- Main Outcome
- Effects of ginsenoside Rg1 on body weight, FGB, and insulin Relationship of the gut microflora with biochemical parameters Impacts of ginsenoside Rg1 on oxidative stress and inflammatory response
- Outcome Measure
- Additional Outcome
- Impacts of ginsenoside Rg1 on the gut microflora diversity Impacts of ginsenoside Rg1 on the gut microbiota composition
- Study Method
- Systematic review
- Keyword
- Diabetes Mellitus, Type 2; Ginsenosides; Humans; Intestinal Diseases; ginsenoside Rg1
- Contact
- Qian Xie [email protected]
- Organisational Affiliation
- Chengdu University of TCM
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-12-21
- Registration Date
- 2023-01-01
- Anticipated Start Date
- 2022-12-20
- Anticipated Completion Date
- 2023-05-30
- Title Cn
- 人参皂苷Rg1抗2型糖尿病肠病的临床前证据：一项Meta分析和系统评价
- Title En
- Preclinical evidence for Ginsenoside Rg1 against Type 2 Diabetes Mellitus bowel disease: a meta‑analysis and systematic review
- Bilingual Status
- complete