Meta AnalysisID 2523
二高-γ-亚麻酸治疗中重度特应性皮炎的有效性和安全性：随机对照试验的系统评价与Meta分析
CRD42023389309
Is oral supplemenation of Dihomo-gamma-Linolenic acid (ds107) efficacious and safe for the management of moderate to severe atopic dermatitis?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2523
- Evidence Id
- 11081
- Core Evidence Id
- 11081
- Source Meta Analysis Id
- 2472
- Herb2 Meta Analysis Id
- HBMA002472
- Crd Id
- CRD42023389309
- Title
- The Efficacy and Safety of Dihomo-Gamma-Linolenic Acid for the Managment of Moderate to Severe Atopic Dermatitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Review Question
- Is oral supplemenation of Dihomo-gamma-Linolenic acid (ds107) efficacious and safe for the management of moderate to severe atopic dermatitis?
- Study Type Included
- Randomized Controlled Trials (RCT).
- Condition Being Studied
- Atopic dermatitis (AD) is a chronic inflammatory pruritic skin disease with a worldwide prevalence estimated to be as high as 20% (1). It mainly affects the face, neck, arms, and legs, but less commonly affects the groin and the axilla (2). 1- Williams H, Stewart A, Mutius E von, Cookson W, Anderson HR. Is eczema really on the increase worldwide? Journal of Allergy and Clinical Immunology (2008) 121:947-954.e15. doi: 10.1016/j.jaci.2007.11.004. 2- Spergel JM. From atopic dermatitis to asthma: the atopic march. Annals of Allergy, Asthma & Immunology (2010) 105:99–106. doi: 10.1016/j.anai.2009.10.002.
- Participant
- Inclusion Criteria: 1-Male or female adults and adolescents (≥12 years) 2-Chronic AD as defined by Hanifin and Rajka (1980) or American Academy of Dermatology Consensus Criteria. 3-≥10% body surface area (BSA) of atopic dermatitis involvement at the baseline visit.
- Animal
- Human Disease Modelled
- Intervention
- Oral Dihomo-gamma-Linolenic acid (ds107) pills.
- Comparator Control
- Placebo Control arm with matched characteristics.
- Main Outcome
- 1- EASI (Eczema Area and Severity Index). 2- NRS (Numeric Rating Scale). 3- IGA (Investigator's Global Assessment). 4- BSA (Body Surface Area). 5- POEM (Patient Orientated Eczema Measure). 6- SCORAD (Scoring of Atopic Dermatitis). Measures of effect Standardized Mean Difference (SMD) mean difference (MD) Risk Ratio (RR)
- Outcome Measure
- Additional Outcome
- not applicable Measures of effect not applicable
- Study Method
- Meta-analysis, Systematic review
- Keyword
- 8,11,14-Eicosatrienoic Acid; Dermatitis, Atopic; Humans; Randomized Controlled Trials as Topic; Severity of Illness Index
- Contact
- Abdulaziz aljuaid [email protected]
- Organisational Affiliation
- College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
- Funding Source
- is oral supplemenation of Dihomo-gamma-Linolenic acid (ds107) efficacious and safe for the management of moderate to severe atopic dermatitis?none
- Other Selection Criteria
- Final Publication
- Same Topic Review
- not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Saudi Arabia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-04
- Registration Date
- 2023-01-15
- Anticipated Start Date
- 2023-01-04
- Anticipated Completion Date
- 2023-02-06
- Title Cn
- 二高-γ-亚麻酸治疗中重度特应性皮炎的有效性和安全性：随机对照试验的系统评价与Meta分析
- Title En
- The Efficacy and Safety of Dihomo-Gamma-Linolenic Acid for the Managment of Moderate to Severe Atopic Dermatitis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
- Bilingual Status
- complete