Meta AnalysisID 2517
血清和支气管肺泡灌洗液半乳甘露聚糖抗原检测用于血液系统恶性肿瘤患者侵袭性肺曲霉病的诊断
CRD42021248572
1. What is the optimal cut-off value of the serum galactomannan OD index for the detection of pulmonary aspergillosis and what is the sensitivity and specificity? 2. What is the optimal cut-off value of the BAL galactoma
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Record Fields
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- Meta Analysis Id
- 2517
- Evidence Id
- 11075
- Core Evidence Id
- 11075
- Source Meta Analysis Id
- 2467
- Herb2 Meta Analysis Id
- HBMA002467
- Crd Id
- CRD42021248572
- Title
- Serum and broncho alveolar lavage galactomannan antigen detection for the diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies
- Review Question
- 1. What is the optimal cut-off value of the serum galactomannan OD index for the detection of pulmonary aspergillosis and what is the sensitivity and specificity? 2. What is the optimal cut-off value of the BAL galactomannan OD index for the detection of pulmonary aspergillosis and what is the sensitivity and specificity? 3. Is it useful to test the serum galactomannan bi-weakly for early screening on pulmonary aspergillosis? 4. Is it useful to test the serum galactomannan bi-weakly during anti-fungal treatment to measure response to therapy?
- Study Type Included
- No restrictions
- Condition Being Studied
- Patients with hematological malignancies are often treated with chemotherapy, thus making them immunocompromised. This greatly increases their risk for opportunistic infections such as invasive pulmonary aspergillosis which is a major cause of mortality and morbidity in this patient group. Early diagnosis and treatment are therefore an important cornerstone in the survival of these patients. Invasive pulmonary aspergillosis is a fungal infection of the lungs and is mostly caused bij the species A. fumigatus. It shows symptoms of fever, chest pain, shortness of breath, coughing and hemoptysis.
- Participant
- The population being studied will be 18+ patients with an hematological malignancy suspected of having invasive pulmonary aspergillosis.
- Animal
- Human Disease Modelled
- Intervention
- We will review the usefulness of the serum and broncho alveolar lavage galactomannan antigen assay in the diagnosis of invasive pulmonary aspergillosis. We will asses the sensitivity and specificity for different cut-off values of the OD-index.
- Comparator Control
- Not applicable
- Main Outcome
- Sensitivity and specificity of the serum and BAL galactomannan OD index at different cut-off values.
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Diagnostic, Systematic review
- Keyword
- Hematologic Neoplasms; Humans; Invasive Pulmonary Aspergillosis; Mannans; Therapeutic Irrigation; galactomannan
- Contact
- Lydia Bukkems [email protected]
- Organisational Affiliation
- Maxima Medical Center https://www.mmc.nl
- Funding Source
- Maxima Medical Center
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Netherlands
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-04-13
- Registration Date
- 2021-05-14
- Anticipated Start Date
- 2021-03-21
- Anticipated Completion Date
- 2021-07-23
- Title Cn
- 血清和支气管肺泡灌洗液半乳甘露聚糖抗原检测用于血液系统恶性肿瘤患者侵袭性肺曲霉病的诊断
- Title En
- Serum and broncho alveolar lavage galactomannan antigen detection for the diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies
- Bilingual Status
- complete