Meta AnalysisID 2501
柑橘黄烷酮与实验性阿尔茨海默病：系统评价和Meta分析
CRD42019143340
To correlate the protective role of citrus flavanones against Alzheimer's disease in rodents. Context and rationale Notwithstanding several studies have been conducted to evaluate the pharmacological action and mechanism
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Record Fields
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- Meta Analysis Id
- 2501
- Evidence Id
- 11059
- Core Evidence Id
- 11059
- Source Meta Analysis Id
- 2451
- Herb2 Meta Analysis Id
- HBMA002451
- Crd Id
- CRD42019143340
- Title
- Citrus Flavanones and Experimental Alzheimer's Disease: A Systematic Review and Meta-Analysis
- Review Question
- To correlate the protective role of citrus flavanones against Alzheimer's disease in rodents. Context and rationale Notwithstanding several studies have been conducted to evaluate the pharmacological action and mechanisms of Naringin, naringenin, hesperidin and hesperetin in animal models for Alzheimer’s disease, there is no comprehensive systematic review and meta-analysis on the benefical role these citrus flavanones in Alzheimer's disease.
- Study Type Included
- Inclusion criteria: Case-control studies; Controlled studies with normal control and Alzheimer'disease control groups. Exclusion criteria: RCTs; cross sectional studies; studies without separate control groups
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: All rodent animal models, with no restriction on species, age, or sex Exclusion criteria: Disease model; Alzheimer's disease
- Human Disease Modelled
- Alzheimer's Disease (AD), a chronic central nervous system degenerative disease characterized by progressive cognitive dysfunction, mental impairment, and emotional abnormalities.
- Intervention
- Inclusion criteria: Intervention included citrus flavanones (only naringin, naringenin, hesperidin and hesperetin were included); no limit to dosage form, frequency and dosage. Exclusion criteria: Intervention that include co-administration of other medicines along with citrus flavanones (naringin, naringenin, hesperidin and hesperetin).
- Comparator Control
- Inclusion criteria: Control include animal models of Alzheimer's disease receiving no treatment, blank or/and sham-operation. Exclusion criteria: Controls which have taken other interventions in addition to citrus flavanones (naringin, naringenin, hesperidin and hesperetin).
- Main Outcome
- Outcome Measure
- Inclusion criteria: (a) oxidative stress markers (SOD, GSH and MDA levels、catalase activity). (b) enzymes concentration (acetylcholinesterase levels). (c) Nitrite levels. (d) cognitive functions parameters(The Morris water maze test and the Y-maze test was used to evaluate cognitive functions in animal models). Exclusion criteria: (a) oxidative stress markers (SOD, GSH and MDA levels、catalase activity) were not measured before and after intervention. (b) enzymes concentration (acetylcholinesterase levels) and nitrite levels were not measured before and after intervention. (c) cognitive functions parameters(The Morris water maze test and the Y-maze test was not used to evaluate cognitive functions in animal models).
- Additional Outcome
- Study Method
- Keyword
- Alzheimer Disease; Animals; Citrus; Flavanones
- Contact
- Rongrong Du [email protected]
- Organisational Affiliation
- Department of Pharmacy, The First Hospital of China Medical University School of Pharmaceutical Science, China Medical University
- Funding Source
- This project is being supported by the National Natural Science Foundation of China [grant number 81302841] as well as the University Outstanding Talent Support Plan Foundation of Liaoning Province [grant number LJQ2014086]
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-07-22
- Registration Date
- 2019-08-23
- Anticipated Start Date
- 2019-06-26
- Anticipated Completion Date
- 2020-04-01
- Title Cn
- 柑橘黄烷酮与实验性阿尔茨海默病：系统评价和Meta分析
- Title En
- Citrus Flavanones and Experimental Alzheimer's Disease: A Systematic Review and Meta-Analysis
- Bilingual Status
- complete