Meta AnalysisID 2493
探讨来曲唑对PCOS女性生育能力的影响
CRD42022376611
Does Letrozole increase ovulation rate, endometrial thickness and the rate of pregnancy compared to Chlomiphene citrate?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2493
- Evidence Id
- 11051
- Core Evidence Id
- 11051
- Source Meta Analysis Id
- 2444
- Herb2 Meta Analysis Id
- HBMA002444
- Crd Id
- CRD42022376611
- Title
- Investigating the effect of Letrozole on fertility in women with PCOS
- Review Question
- Does Letrozole increase ovulation rate, endometrial thickness and the rate of pregnancy compared to Chlomiphene citrate?
- Study Type Included
- Inclusion criteria: we are planning to include RCT studies in our research work. Exclusion criteria: we are planning to exclude reviews, cases series, cases reports.
- Condition Being Studied
- Polycystic ovarian syndrome (PCOS) is one of the most common endocrine disorders, characterized by irregular menstrual cycles, hyperandrogenism, and polycystic ovaries. Clomiphene citrate (CC) is the drug of first choice for ovulation induction in women with PCOS in the past 55 years, however, it thins the endometrium via its anti-estrogenic effect and has several side effects (vasomotor reaction, headache, nausea, and breast tenderness) as well. Aromatase inhibitors are new promising ovulation-inducing agents. The efficacy of Letrozole, a selective aromatase inhibitor, is heavily investigated, demonstrating its potential superiority to clomiphene citrate in terms of live birth, pregnancy and ovulation rates, while not having an endometrium thinning effect. Our aim is to compare the efficacy of Letrozole therapy to Clomiphene citrate therapy in women with PCOS.
- Participant
- women with PCOS
- Animal
- Human Disease Modelled
- Intervention
- Letrozole therapy
- Comparator Control
- Chlomiphene citrate therapy
- Main Outcome
- Primary outcomes: Endometrial thickness, number of dominant follicles, ovulation rates, pregnancy rates Secondary outcomes: Should data volume permit, the following outcomes will be analyzed as well endometrial volume Measures of effect Risk ratios (RR) or Odds ratios (OR) for dichotomous outcomes, Weighted- or standardized mean difference (WMD or SMD) for continuous ones.
- Outcome Measure
- Additional Outcome
- None. Measures of effect None.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Citrates; Female; Fertility; Humans; Letrozole; Ovulation; Polycystic Ovary Syndrome; Pregnancy
- Contact
- Rita Zsuzsanna Vajna [email protected]
- Organisational Affiliation
- Semmelweis University Centre for Translational Medicine www.tm-centre.org
- Funding Source
- None. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Hungary
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-17
- Registration Date
- 2022-11-28
- Anticipated Start Date
- 2022-09-01
- Anticipated Completion Date
- 2023-06-01
- Title Cn
- 探讨来曲唑对PCOS女性生育能力的影响
- Title En
- Investigating the effect of Letrozole on fertility in women with PCOS
- Bilingual Status
- complete