Meta AnalysisID 2492
来曲唑对多囊卵巢综合征(PCOS)患者子宫内膜容受性(ER)的作用：随机对照试验的系统评价和Meta分析
CRD42022343725
This meta-analysis summarizes evidence from studies using letrozole to improve endometrial receptivity (ER) in women with PCOS
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Record Fields
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- Meta Analysis Id
- 2492
- Evidence Id
- 11050
- Core Evidence Id
- 11050
- Source Meta Analysis Id
- 2443
- Herb2 Meta Analysis Id
- HBMA002443
- Crd Id
- CRD42022343725
- Title
- The function of letrozole in endometrial receptivity (ER) of patients with polycystic ovary syndrome (PCOS): a systematic review and meta-analysis of randomized controlled trials.
- Review Question
- This meta-analysis summarizes evidence from studies using letrozole to improve endometrial receptivity (ER) in women with PCOS
- Study Type Included
- RCT test published at home and abroad, language limited to English
- Condition Being Studied
- Both clomiphene and letrozole are ovulatory drugs commonly used in anovulatory women with PCOS, but in recent years, numerous studies have shown that letrozole seems to improve live birth (LB) and pregnancy rates in ovulation women with PCOS compared with clomifene.So what why letrozole increases the live birth and pregnancy rate in PCOS anovulatory women?Through a systematic review of various related studies, we found that letrozole can effectively improve the endometrial tolerance, and thus improve the pregnancy rate. During recent years, assisted reproductive technolo- gies (ARTs), such as IUI, in vitro fertilization (IVF) and embryo transfer (ET), have become increasingly popular. Move over, the prognosis of ART treatment for infertil- ity patients has greatly improved; however, some patients still cannot achieve clinical pregnancy after re- ceiving multiple high-quality embryo transfers. There are many causes that may explain such implantation fail- ure, and endometrial receptivity (ER) is critical.By definition, ER refers to the ability of the endometrium to allow the blastula to locate, adhere, invade, and ultim- ately implant during the period when the endometrium matures (luteal phase) . A successful pregnancy re- quires synchronization of the development of the em- bryo and a receptive endometrium .
- Participant
- Inclusion: ①Study type: RCT test published at home and abroad, language limited to English；②Study subjects: meet the relevant diagnostic criteria for PCOS；③subjects received treatment alone or in combination, and indicators related to ER were assessed. Exclusion: ①The study type was not clearly specified；②Effective outcome data cannot be extracted from the original literature；③Repeat publication；④Cannot get full text；⑤The study subjects were combined with other endocrine disorders；⑥The intervention was unclear.
- Animal
- Human Disease Modelled
- Intervention
- letrozole used alone or in combination
- Comparator Control
- Clomiphene or others
- Main Outcome
- EMT, endometrium artery RI, endometrial volume (EV), vascularization index (VI), flow index (FI), vascularization flow index (VFI)，main ligands of Wnt/β-catenin Measures of effect The meta-analysis was conducted using Cochrane Re- view Manager software (RevMan 5.3). Continuous out- comes were measured by Std mean differences (SMDs) and dichotomous outcomes by risk ratios (RRs), both with 95% confidence intervals (CIs).
- Outcome Measure
- Additional Outcome
- clinical pregnancy rate, and miscarriage rate Measures of effect Continuous out- comes were measured by Std mean differences (SMDs) and dichotomous outcomes by risk ratios (RRs), both with 95% confidence intervals (CIs).
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Clomiphene; Female; Fertility Agents, Female; Humans; Letrozole; Polycystic Ovary Syndrome; Randomized Controlled Trials as Topic
- Contact
- Wang Wenwen [email protected]
- Organisational Affiliation
- Chengdu University of Traditional Chinese Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-07-01
- Registration Date
- 2022-07-12
- Anticipated Start Date
- 2022-06-20
- Anticipated Completion Date
- 2022-07-30
- Title Cn
- 来曲唑对多囊卵巢综合征(PCOS)患者子宫内膜容受性(ER)的作用：随机对照试验的系统评价和Meta分析
- Title En
- The function of letrozole in endometrial receptivity (ER) of patients with polycystic ovary syndrome (PCOS): a systematic review and meta-analysis of randomized controlled trials.
- Bilingual Status
- complete