Meta AnalysisID 2491
来曲唑相关方案治疗子宫内膜异位症的网状Meta分析
CRD42022327816
The purpose of this network meta-analysis of randomized controlled trial is to evaluate the optimal use of letrozole for endometriosis.
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Record Fields
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- Meta Analysis Id
- 2491
- Evidence Id
- 11049
- Core Evidence Id
- 11049
- Source Meta Analysis Id
- 2442
- Herb2 Meta Analysis Id
- HBMA002442
- Crd Id
- CRD42022327816
- Title
- A Network Meta-analysis of Letrozole-related regimens in the Treatment of Endometriosis
- Review Question
- The purpose of this network meta-analysis of randomized controlled trial is to evaluate the optimal use of letrozole for endometriosis.
- Study Type Included
- Randomized controlled trial.blind method and follow-up unlimited
- Condition Being Studied
- Endometriosis refers to the implantation of active endometrial tissue (glands and stroma) outside the uterine cavity. It is an aggressive, recurrent chronic estrogen-dependent benign disease. Patients may have secondary dysmenorrhea, chronic pelvic pain, painful intercourse, anal falling pain, infertility, pelvic nodules or masses and other gynecological symptoms. Endometriosis has extensive lesions and various forms. It has the ability of tumor invasion and metastasis and is highly recurrent. It is known as the deathless cancer and has a serious impact on women's health, work, study and quality of life. Endometriosis has always been a hot and difficult research topic for obstetricians and gynecologists. Letrozole is a highly selective non-steroidal aromatase inhibitor, which can specifically competitively bind to aromatase binding sites, reduce estrogen synthesis, and narrow ectopic lesions. Currently, letrozole can be used alone in the treatment of endometriosis. Letrozole in combination with didrogesterone, mifistone, getrienone, GnRHa, metformin, etc., may also be used, but there is no clear evidence directly on which regimen is best.
- Participant
- Patients with endometriosis diagnosed by clinical symptoms, signs, ultrasound or laparoscopy
- Animal
- Human Disease Modelled
- Intervention
- Letrozole was used for treatment
- Comparator Control
- Letrozole is used in combination with other drugs or other medications
- Main Outcome
- The primary outcome measure was efficiency. Significant effect: clinical symptoms such as pain and sexual discomfort disappeared completely or no pelvic mass was found in B ultrasound examination. Effective: After b-ultrasonography examination, pelvic mass was reduced, and occasionally pain or significant pain relief. Ineffective: pelvic mass did not shrink, pain did not relieve or worsen. Effective = (effective + effective)/Total number of people ×100%. Measures of effect odds ratios
- Outcome Measure
- Additional Outcome
- The levels of estrogen and carcinoembryonic antigen 125(CA125) after treatment, adverse reactions. Measures of effect Continuous variables were evaluated by Mean different(MD) and dichotomous variables by odds ratios(OR).
- Study Method
- Intervention, Network meta-analysis, Systematic review
- Keyword
- Endometriosis; Female; Humans; Letrozole; Network Meta-Analysis; Nitriles; Triazoles
- Contact
- Aiping [email protected]
- Organisational Affiliation
- Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. https://www.gxmuyfy.cn/
- Funding Source
- no Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> no
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-23
- Registration Date
- 2022-05-10
- Anticipated Start Date
- 2022-04-23
- Anticipated Completion Date
- 2022-07-31
- Title Cn
- 来曲唑相关方案治疗子宫内膜异位症的网状Meta分析
- Title En
- A Network Meta-analysis of Letrozole-related regimens in the Treatment of Endometriosis
- Bilingual Status
- complete