Meta AnalysisID 2469
S-甲基半胱氨酸对实验性糖尿病动物血糖、氧化应激和炎症的影响：一项系统评价
CRD42022272907
What are the effects of s-methyl cysteine on blood glucose, oxidative stress and inflammation in experimentally diabetic animals? Context and rationale Diabetes mellitus (DM) is a metabolic disorder that, in the long ter
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Record Fields
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- Meta Analysis Id
- 2469
- Evidence Id
- 11027
- Core Evidence Id
- 11027
- Source Meta Analysis Id
- 2418
- Herb2 Meta Analysis Id
- HBMA002418
- Crd Id
- CRD42022272907
- Title
- Effects of s-methyl cysteine on blood glucose, oxidative stress and inflammation in experimentally diabetic animals: a systematic review.
- Review Question
- What are the effects of s-methyl cysteine on blood glucose, oxidative stress and inflammation in experimentally diabetic animals? Context and rationale Diabetes mellitus (DM) is a metabolic disorder that, in the long term, is related to complications and failure of various organs (1). Its main characteristic is chronic hyperglycemia (2). This disease occurs in three main forms, Diabetes Mellitus Type I (DM1), Diabetes Mellitus Type II (DM2) and Gestational Diabetes Mellitus (3). Considered a worldwide epidemic, it is estimated that 2, 045, 700 million adults have already developed the disease, a number equivalent to 10% of the world population (4). During the course of the disease, the development of a series of associated complications (microvascular and macrovascular) that increase morbidity and mortality rates is common (5). Among the mechanisms involved in inducing these damages are oxidative stress and inflammation (1). In recent years, many studies have explored the therapeutic potential of natural substances for diabetic complications, including s-methyl cysteine, which is an amino acid present in vegetables such as garlic and onions. In the current literature on animal experiments, it has already been observed that the amino acid in question has a hypoglycemic effect as well as reducing the expression of inflammatory and oxidative molecules in tissues of diabetic animals. Based on these results already described, we believe that similar results can be found in diabetic patients, considering that the animal model seeks to mimic the human disease. Furthermore, as it is widely present in the world's diet and because of its easy access to the amino acid, it can be further explored as to its effects on diabetes and, in the future, it may become an alternative or adjuvant therapy for Diabetes Mellitus. Thus, the present study intends to systematically review the effects of this amino acid on blood glucose and markers of oxidative stress and inflammation in diabetic animals.
- Study Type Included
- Inclusion criteria: Controlled studies with a separate diabetic control group and a diabetic group treated with s-methylcysteine. Exclusion criteria: Studies without a separate control group, clinical studies, case studies and crossover studies.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Any animal model of diabetes mellitus. Exclusion criteria: Co-human, ex vivo, in vitro and in silico studies.
- Human Disease Modelled
- Diabetes Mellitus
- Intervention
- Inclusion criteria: Supplementation with S-methyl cysteine sulfoxide. Exclusion criteria: Other treatments other than s-methyl cysteine.
- Comparator Control
- Inclusion criteria: Untreated diabetic group. Exclusion criteria: Control group without diabetes and treatments that are not of interest.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Blood glucose levels, oxidative stress and inflammation markers. Exclusion criteria: Morphological parameters.
- Additional Outcome
- Study Method
- Keyword
- Animals; Blood Glucose; Diabetes Mellitus, Experimental; Inflammation; Oxidative Stress; Streptozocin; mecysteine
- Contact
- Valéria Milena Dantas de Castro [email protected]
- Organisational Affiliation
- Universidade Federal Rural do Pernambuco
- Funding Source
- There is no funding agency for this research.
- Other Selection Criteria
- Review studies will be excluded. No publication date and language limitations will apply.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-09-14
- Registration Date
- 2022-02-22
- Anticipated Start Date
- 2021-09-14
- Anticipated Completion Date
- 2022-03-14
- Title Cn
- S-甲基半胱氨酸对实验性糖尿病动物血糖、氧化应激和炎症的影响：一项系统评价
- Title En
- Effects of s-methyl cysteine on blood glucose, oxidative stress and inflammation in experimentally diabetic animals: a systematic review.
- Bilingual Status
- complete