Meta AnalysisID 2464
每日口服600mg N-乙酰半胱氨酸对特发性不育男性精液参数和血清激素影响的作用：一项随机对照试验的系统评价与Meta分析
CRD42020209000
The effect of 600mg N-acetyl-cysteine orally daily on the sperm parameters and serum hormones in idiopathic infertile men from meta-analysis of randomized controlled trials
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2464
- Evidence Id
- 11022
- Core Evidence Id
- 11022
- Source Meta Analysis Id
- 2413
- Herb2 Meta Analysis Id
- HBMA002413
- Crd Id
- CRD42020209000
- Title
- The role of 600mg N-acetyl-cysteine orally daily on the sperm parameters and serum hormones in idiopathic infertile men: a systematic review and meta-analysis of randomized controlled trials
- Review Question
- The effect of 600mg N-acetyl-cysteine orally daily on the sperm parameters and serum hormones in idiopathic infertile men from meta-analysis of randomized controlled trials
- Study Type Included
- RCT；The following studies were excluded: not RCT, such as abstract, review, or comment; patients with urogenital bacterial infection, smoke, hypogonadism, varicocele, the use of drugs and other comorbidities; other treatment.
- Condition Being Studied
- Infertility is a disease that it is incapable to become pregnant after at least 1 year of regular unprotected intercourse, and male factors accounting for nearly half of the reported patients are considered to be secondary to testicular dysfunction or reproductive tract occlusion. Oxidative stress and reactive oxygen species (ROS) are highly active oxidants that can be classified as endogenous or exogenous according to their sources, which may lead to spermatogenesis defects and male infertility. Currently, physiological and genetic factors may also be related to sperm function and the occurrence of infertility. In particular, oxidative stress (OS) is considered to be an important factor affecting male fertility and sperm physiological function. Under normal conditions, the active oxygen produced by male sperm is less, which is necessary for normal sperm function (sperm activation, capacitation, acrosome reaction) and natural fertilization. Pathological ROS production results in lipid peroxidation of male spermatozoa, reduces the quality of semen and damages sperm DNA by forming single and/or double. Reducing excess ROS production is very important for sperm to maintain normal function and fertilization ability.
- Participant
- The sperm parameters of patients with primary infertility were normal. According to the history, physical examination and semen examination results, there were no factors that might affect male infertility. This study only included patients with idiopathic infertility with normal sperm parameters, and there were no previous factors that could affect male fertility, failed attempts at conception and no female factors.
- Animal
- Human Disease Modelled
- Intervention
- 600mg N-acetyl-cysteine orally daily；
- Comparator Control
- Non-exposed control group；
- Main Outcome
- sperm concentration, ejaculate volume, sperm motility, normal morphology, testosterone, luteinizing hormone, follicle stimulating hormone and prolactin. Measures of effect mean difference (MD)
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Intervention, Meta-analysis, Review of reviews, Systematic review
- Keyword
- Cysteine; Hormones; Humans; Male; Randomized Controlled Trials as Topic; Sperm Count; Spermatozoa
- Contact
- Yuanshan Cui [email protected]
- Organisational Affiliation
- Yantai Yuhuangding Hospital; Beijing Tiantan Hospital;
- Funding Source
- Beijing Municipal Administration of Hospitals’ Ascent Plan Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Code: DFL20190502
- Other Selection Criteria
- Final Publication
- The role of N-acetyl-cysteine (NAC) orally daily on the sperm parameters and serum hormones in idiopathic infertile men: A systematic review and meta-analysis of randomised controlled trials. Zhou Z, Cui Y, Zhang X, Zhang Y. Andrologia. 2021 Mar;53(2):e13953. doi: 10.1111/and.13953. Epub 2021 Jan 6. PMID: 33405232
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed published
- First Submission Date
- 2020-09-12
- Registration Date
- 2020-10-12
- Anticipated Start Date
- 2020-09-30
- Anticipated Completion Date
- 2021-02-28
- Title Cn
- 每日口服600mg N-乙酰半胱氨酸对特发性不育男性精液参数和血清激素影响的作用：一项随机对照试验的系统评价与Meta分析
- Title En
- The role of 600mg N-acetyl-cysteine orally daily on the sperm parameters and serum hormones in idiopathic infertile men: a systematic review and meta-analysis of randomized controlled trials
- Bilingual Status
- complete