Meta AnalysisID 2463
N-乙酰半胱氨酸在改善非对乙酰氨基酚所致急性肝衰竭患者死亡率中的作用
CRD42020163877
Does the use of N-acetylcysteine significantly improve the transplant free survival of patients suffering from non-acetaminophen induced acute liver failure? Does the use of N-acetylcysteine significantly improve the pos
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Record Fields
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- Meta Analysis Id
- 2463
- Evidence Id
- 11021
- Core Evidence Id
- 11021
- Source Meta Analysis Id
- 2412
- Herb2 Meta Analysis Id
- HBMA002412
- Crd Id
- CRD42020163877
- Title
- Role of N-acetyl cysteine in improving mortality in patients of non-acetaminophen induced acute liver failure
- Review Question
- Does the use of N-acetylcysteine significantly improve the transplant free survival of patients suffering from non-acetaminophen induced acute liver failure? Does the use of N-acetylcysteine significantly improve the post transplant survival of patients suffering from non-acetaminophen induced acute liver failure?
- Study Type Included
- Randomized controlled trials, retrospective and prospective observational
- Condition Being Studied
- The condition being studied is the onset of acute liver failure which may have any etiology other than acetaminophen use/toxicity.
- Participant
- All patients suffering from Acute Liver Failure brought on by any cause other than acetaminophen toxicity. Our patient population included both pediatric and adult patients
- Animal
- Human Disease Modelled
- Intervention
- The intervention was N-acetyl cysteine given either orally or intravenously. In case of IV administration, the following patterns were included: 1. Continuous intravenous infusion (100 mg/kg/24 hours) until normalization of the INR, death, or transplantation 2. Administered as a loading dose of 150 mg/kg per hour over 1 hour, followed by a continuous infusion of 12.5 mg/kg per hour for 4 hours and then 6.25 mg/kg per hour for an additional 67 hours 3. 150 mg/kg daily for seven days 4. An infusion of 150 mg/kg over 30 min, followed by 70 mg/kg over 4 h, then 70 mg/kg over 16 h. Subsequently, a continuous infusion of 150 mg/kg in 500 ml dextrose 5% over 24 h was continued until two consecutive INR results of less than 1.3 with improving LFT. Administration of oral NAC was at a dose of 140 mg/kg, followed by 70 mg/kg, for a total of 17 doses, 4 h apart within 6 h of admission
- Comparator Control
- The control group was given the standard treatment for ALF with/without placebo. Standard treatment involved continuous intravenous dextrose infusion to prevent hypoglycemia; broad-spectrum prophylactic antimicrobials to preventbacterial and fungal infections, and ranitidineand/or sucralfate to prevent acute gastrointestinalbleeding. Fresh frozen plasma was only given if an invasive procedure needed to be done
- Main Outcome
- Transplant free survival, and post transplant survival Measures of effect Odds ratios would be compared for each category.
- Outcome Measure
- Additional Outcome
- Length of hospital stay, frequency of complications such as renal failure, encephalopathy, infections, etc Measures of effect Odds ratios would be compared for each category.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Humans
- Contact
- Haris Jawaid [email protected]
- Organisational Affiliation
- Dow University of Health Sciences
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Pakistan
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-02-04
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-01-15
- Anticipated Completion Date
- 2020-03-15
- Title Cn
- N-乙酰半胱氨酸在改善非对乙酰氨基酚所致急性肝衰竭患者死亡率中的作用
- Title En
- Role of N-acetyl cysteine in improving mortality in patients of non-acetaminophen induced acute liver failure
- Bilingual Status
- complete