Meta AnalysisID 2461
儿童和青少年同型半胱氨酸和半胱氨酸水平与心血管危险因素：一项系统评价与Meta分析
CRD42018086252
Are high levels of homocysteine and cysteine associated with cardiovascular risk factors in children and adolescents? PICOS: P (Population): children and adolescents; I/E (Intervention/Exposure): high levels of homo
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Record Fields
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- Meta Analysis Id
- 2461
- Evidence Id
- 11019
- Core Evidence Id
- 11019
- Source Meta Analysis Id
- 2410
- Herb2 Meta Analysis Id
- HBMA002410
- Crd Id
- CRD42018086252
- Title
- Homocysteine and cysteine levels and cardiovascular risk factors in children and adolescents: a systematic review and meta-analysis
- Review Question
- Are high levels of homocysteine and cysteine associated with cardiovascular risk factors in children and adolescents? PICOS: P (Population): children and adolescents; I/E (Intervention/Exposure): high levels of homocysteine and cysteine; C (Comparator): appropriate levels of homocysteine and cysteine; O (Outcomes): cardiovascular risk factors; S (Study type): observational studies.
- Study Type Included
- Inclusion: we will only include observational studies that present results of statistical analysis between homocysteine and cysteine levels (exposition variable) and cardiovascular risk factors (outcome variables) in children an adolescents. Inclusion criteria summary: • Study design: observational; • Study population are children and adolescents; • No time criteria will be used for published studies; • Exposition: homocysteine and cysteine high levels; • Comparison: homocysteine and cysteine normal levels. Exclusion: interventional studies; clinical trial studies; in vitro and in vivo studies; review studies and / or case reports; studies that do not evaluate the outcome.
- Condition Being Studied
- Evidence that chronic diseases in adulthood are shaped in childhood and adolescence are consistent. Thus, in recent years, many studies have been devoted to the identification of cardiovascular risk factors during childhood and adolescence, in which they have been designed with increasing tendency and already constitute an important cause of morbidity in this life cycles, being highlighted obesity, dyslipidemias and arterial hypertension and type 2 diabetes. Several studies have pointed to homocysteine and cysteine as markers for cardiovascular diseases, whose plasma values may contribute to early identification of cardiovascular risk, since hyperhomocysteinemia and hypercysteinemia have been shown cardiovascular risk factors independent of the others. Studies of children and adolescents have indicated that even in the pediatric age group, elevated homocysteine levels are associated with elevated systolic blood pressure and weight gain. In addition, levels are higher in children who have a parent, grandfather or uncle with early death from cardiovascular disease. Although evidence suggests that hyperhomocysteinemia and hypercysteinemia are risk factors for cardiovascular disease in adults, there is little information on homocysteine and cysteine levels in adolescents. Studying this relationship becomes indispensable, contributing to early identification of cardiovascular risk in this ages groups and primary prevention of other chronic diseases in adulthood.
- Participant
- Inclusion: children and adolescents.
- Animal
- Human Disease Modelled
- Intervention
- High homocysteine and cysteine high levels and the association with the development of cardiovascular risk factors in children and adolescents (overweight, obesity abdominal, systolic blood pressure, diastolic blood pressure, serum lipids, insulin resistance and glucose levels).
- Comparator Control
- We will compare the prevalence or mean values of the cardiovascular risk factors (overweight, obesity abdominal, systolic blood pressure, diastolic blood pressure, serum lipids, insulin resistance and glucose levels) in the group exposed to the high levels of homocysteine and cysteine and the group non-exposed.
- Main Outcome
- The outcomes for this study include the relative risk (OR) or the mean value of fasting blood glucose; HOMA-IR, plasma insulin, high density lipoprotein cholesterol (HDL-c); low density lipoprotein cholesterol (LDL-c); total cholesterol (TC); triacylglycerol (TAG); very low density lipoprotein (VLDL); systolic blood pressure (SBP); diastolic blood pressure (DBP); body mass index (BMI); waist circumference (WC). Measures of effect Relative risk (RR), prevalence ratio (PR) or odds ratio (OR) with their confidence intervals (CI) for categorical risk estimates; mean values and standard deviation or correlation coefficient with respective p values for continuous variables.
- Outcome Measure
- Additional Outcome
- None. Measures of effect Not applicable.
- Study Method
- Epidemiologic, Meta-analysis, Systematic review
- Keyword
- Adolescent; Cardiovascular Diseases; Cohort Studies; Cysteine; Homocysteine; Humans; Risk Factors
- Contact
- Luana Leite [email protected]
- Organisational Affiliation
- Federal University of Bahia - UFBA www.ufba.br
- Funding Source
- This review has not received any funding sources.
- Other Selection Criteria
- Final Publication
- de Oliveira Leite L, Costa Dias Pitangueira J, Ferreira Damascena N, Ribas de Farias Costa P. Homocysteine levels and cardiovascular risk factors in children and adolescents: systematic review and meta-analysis. Nutr Rev. 2021 Aug 9;79(9):1067-1078. doi: 10.1093/nutrit/nuaa116. PMID: 33351941. doi:
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, Portuguese-Brazil
- Country
- Brazil
- Review Stage
- Review Completed published
- First Submission Date
- 2018-01-16
- Registration Date
- 2018-01-25
- Anticipated Start Date
- 2018-01-07
- Anticipated Completion Date
- 2019-01-31
- Title Cn
- 儿童和青少年同型半胱氨酸和半胱氨酸水平与心血管危险因素：一项系统评价与Meta分析
- Title En
- Homocysteine and cysteine levels and cardiovascular risk factors in children and adolescents: a systematic review and meta-analysis
- Bilingual Status
- complete