Meta AnalysisID 2460
使用N-乙酰半胱氨酸预防噪声性听力损失：一项临床试验的系统评价
CRD42017068084
The main question in this review relates to the effectiveness of the administration of N-acetyl cysteine (NAC) for preventing noise-induced hearing loss in humans. 1) Does NAC prevent noise-induced hearing loss? 2) Does
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Record Fields
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- Meta Analysis Id
- 2460
- Evidence Id
- 11018
- Core Evidence Id
- 11018
- Source Meta Analysis Id
- 2409
- Herb2 Meta Analysis Id
- HBMA002409
- Crd Id
- CRD42017068084
- Title
- Prevention of noise-induced hearing loss using N-acetyl cysteine: a systematic review of clinical trials
- Review Question
- The main question in this review relates to the effectiveness of the administration of N-acetyl cysteine (NAC) for preventing noise-induced hearing loss in humans. 1) Does NAC prevent noise-induced hearing loss? 2) Does NAC prevent both temporary (transient threshold shift) and permanent (permanent threshold shift) effects? 3) How big is the observed effect size? 4) What are the possible sources of heterogeneity in the literature?
- Study Type Included
- We will include clinical trials appraising the preventive effects of administering NAC to noise-exposed persons.
- Condition Being Studied
- Repeated exposure to loud sounds over an extended period of time, exposure to very loud impulse sound(s), or a combination of both can lead to noise-induced hearing loss (NIHL). The classic proposed mechanism for this is physical damage to the cochlea, but recently, the role of oxidative stress and free radicals have gained attention. Several studies have evaluated the possible efficiency of antioxidants (e.g. NAC) in the prevention of NIHL in both animals and humans, although the results of these studies is not conclusive, and it seems that different study protocols, heterogeneity in therapeutic methods and between-subject variations are the most probable causes of such findings. In this review, we will therefore explore available evidence regarding the role of NAC (as an antioxidant) in humans for the treatment of noise-induced hearing loss.
- Participant
- Inclusion: subjects or groups exposed to noise (occupational or non-occupational). Exclusion: hearing loss due to ototoxic drugs or substances.
- Animal
- Human Disease Modelled
- Intervention
- Oral administration of N-acetyl cysteine. The outcome will be defined as a shift in the hearing threshold measured by pure tone audiometry.
- Comparator Control
- Noise-exposed individuals who have not received NAC.
- Main Outcome
- Changes (or shifts) in hearing thresholds, as measured by pure tone audiometry before and after the administration of NAC to individuals who have experienced noise exposure.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Intervention, Meta-analysis, Prevention, Systematic review
- Keyword
- Acetylcysteine; Hearing; Hearing Loss, Noise-Induced; Humans; Noise; Noise, Occupational; Occupational Exposure; Primary Prevention; Treatment Outcome
- Contact
- Ahmad Shojaaddiny-Ardakani [email protected]
- Organisational Affiliation
- Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2017-06-03
- Anticipated Start Date
- 2016-09-01
- Anticipated Completion Date
- 2017-08-01
- Title Cn
- 使用N-乙酰半胱氨酸预防噪声性听力损失：一项临床试验的系统评价
- Title En
- Prevention of noise-induced hearing loss using N-acetyl cysteine: a systematic review of clinical trials
- Bilingual Status
- complete