Meta AnalysisID 2459
N-乙酰半胱氨酸对高血糖诱导的氧化损伤的心脏保护潜力
CRD42017055851
To systemically assess results of published data and summarize the state of knowledge on the cardioprotective potential of N-acetytl cysteine against hyperglycaemia-induced oxidative injury that may lead to the developme
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Record Fields
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- Meta Analysis Id
- 2459
- Evidence Id
- 11017
- Core Evidence Id
- 11017
- Source Meta Analysis Id
- 2408
- Herb2 Meta Analysis Id
- HBMA002408
- Crd Id
- CRD42017055851
- Title
- Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage
- Review Question
- To systemically assess results of published data and summarize the state of knowledge on the cardioprotective potential of N-acetytl cysteine against hyperglycaemia-induced oxidative injury that may lead to the development of diabetic cardiomyopathy
- Study Type Included
- Types of studies that will be included are original articles, editorials, letters, and articles from the grey literature (e.g. pre-prints and conference proceedings), whilst narrative reviews will only be screened for primary studies. Randomized controlled trials and randomized cross over studies will be eligible.
- Condition Being Studied
- Diabetic cardiomyopathy is a unique clinical entity that is characterised by impaired myocardial substrate metabolism, left ventricular (LV) hypertrophy and diastolic dysfunction. At present, there is no specific treatment for DCM; however, traditional treatment of heart failure and DM are the preferred methods used to contain DCM. First line antidiabetic drugs such as metformin and insulin can prolong the lives of diabetic patients by lowering glucose levels and have been shown to display cardioprotective properties. However, long-term exposure to persistent hyperglycaemia appears to limit the cardioprotective effect of these drugs as shown by an increasing number of CVD-related deaths within diabetic patients. Current consensus is that hyperglycaemia generates overproduction of free radical species, which leads to oxidative stress and subsequent myocardial damage. Hyperglycaemic-induced oxidative stress is believed to directly cause modifications in cardiac structure and function that may occur in the late stage of DM. Therefore, the proposed use of antioxidant therapies to curb intracellular oxidative damage and enhance the effect of current antidiabetic agents is among the leading hypothesis being tested to reduce the risk of myocardial infarction in diabetic patients.
- Participant
- This systematic review is meant to be exploratory, thus descriptive details of the bioactivity that is associated with the cardioprotective effect of N-acetyl cysteine (NAC) against hyperglycaemia and oxidative stress-induced cardiac damage will be reported. The searches will include in vitro and in vivo studies. For in vitro experiments, the included studies will be those that investigate the cardioprotective effect of NAC as a monotherapy or in combination with any other type 2 diabetic drug agent against hyperglycaemic- or/and oxidative-induced stress in cultured immortal and primary cells. In vivo investigations will be those that assess the cardioprotective effect of NAC on heart tissue isolated from diabetic rodent models or human subjects treated with NAC or its combinational use with any other type 2 diabetic agent.
- Animal
- Human Disease Modelled
- Intervention
- N-acetyl cysteine (NAC) has emerged as a strong agent that is increasing studied for its cardioprotective properties. Although increasing studies are available on the bioactivity of NAC, no comprehensive review exists on the cardioprotective potential of NAC against hyperglycaemia-induced oxidative injury that may result in the development of diabetic cardiomyopathy (DCM). Therefore, this systemic review will assess the cardioprotective intervention of NAC against diabetes-associated complications. Specifically focusing on reviewing literature on the protective potential of NAC against hyperglycaemia-induced oxidative damage related to the development of DCM
- Comparator Control
- Extracted data on the cardioprotective properties of N-acetyl cysteine against hyperglycemia-induced oxidative damage will be compared to an untreated control group within that specific study being reported.
- Main Outcome
- This systemic review will address the existing knowledge gap regarding the protective effect of N-acetyl cysteine against diabetic cardiomyopathy as the main outcome, in particular, for the prevention of hyperglycaemia-induced oxidative injury. Measures of effect Not applicable
- Outcome Measure
- Additional Outcome
- N-acetyl cysteine is already listed in the World Health Organization's list of essential medicines, this review may determine whether more research is necessary to establish its use as a protective therapy against diabetic cardiomyopathy. Measures of effect Not applicable
- Study Method
- Intervention, Prevention, Systematic review
- Keyword
- Acetylcysteine; Humans; Hyperglycemia; Oxidation-Reduction; Oxidative Stress
- Contact
- Dr Phiwayinkosi Dludla [email protected]
- Organisational Affiliation
- South African Medical Research Council www.mrc.ac.za
- Funding Source
- South African Medical Research Council
- Other Selection Criteria
- Final Publication
- The protocol was published with Systematic Reviews, while the actual review was published with the American Journal of Cardiovascular Drugs (links provided below) Dludla, P. V., Dias, S. C., Obonye, N., Johnson, R., Louw, J., & Nkambule, B. B. (2018). A Systematic Review on the Protective Effect of N-Acetyl Cysteine Against Diabetes-Associated Cardiovascular Complications. American journal of cardiovascular drugs : drugs, devices, and other interventions, 18(4), 283–298. https://doi.org/10.1007/s40256-018-0275-2 https://www.ncbi.nlm.nih.gov/PubMed/28499416
- Same Topic Review
- Published Protocol
- https://PubMed.ncbi.nlm.nih.gov/28499416/
- Review Type
- Language
- English
- Country
- South Africa
- Review Stage
- Review Completed published
- First Submission Date
- 2019-11-26
- Registration Date
- 2017-01-23
- Anticipated Start Date
- 2017-01-24
- Anticipated Completion Date
- 2017-05-31
- Title Cn
- N-乙酰半胱氨酸对高血糖诱导的氧化损伤的心脏保护潜力
- Title En
- Cardioprotective potential of N-acetyl cysteine against hyperglycaemia-induced oxidative damage
- Bilingual Status
- complete