Meta AnalysisID 2429
丁香酚的抗糖尿病作用：动物研究的Meta分析
CRD42019157503
Is the use of eugenol effective in treating diabetes in murine models? Context and rationale Over the last decades, studies have described several activities of eugenol over diabetes treatment. Even though, the knowledge
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2429
- Evidence Id
- 10987
- Core Evidence Id
- 10987
- Source Meta Analysis Id
- 2378
- Herb2 Meta Analysis Id
- HBMA002378
- Crd Id
- CRD42019157503
- Title
- Antidiabetic effect of eugenol: A meta-analysis of animal studies.
- Review Question
- Is the use of eugenol effective in treating diabetes in murine models? Context and rationale Over the last decades, studies have described several activities of eugenol over diabetes treatment. Even though, the knowledge about its effects is still scarce, which difficults the understanding of its mechanism of action. In addition, a deep and specific meta-analysis of the effect of eugenol over diabetes treatment has yet to be done. Therefore, we believe that this meta-analysis will shed light on the real potential of eugenol as an antidiabetic so that we can consolidate it as a potential medicine for human use.
- Study Type Included
- Inclusion criteria: All study types are eligible as long as they have a diabetic control group and a eugenol-treated diabetic group. Exclusion criteria: Studies published in journals with impact factor less than 1.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: In the meta-analysis, we will include only rodents (rat and mouse) as an animal model of induced-diabetes. Regarding the type of diabetes, both type1 and 2 diabetes will be included in the searching. Exclusion criteria: It will be excluded no rodent animals.
- Human Disease Modelled
- Diabetes mellitus type 1 or type 2.
- Intervention
- Inclusion criteria: We will include studies using clove extracts, clove oil, eugenol purified from plant extracts, as well as eugenol purchased from commercial laboratories. We will include treatments using this compound in different concentrations, routes of administration, frequency of treatment and time. Exclusion criteria: Studies in which it was not clear the presence of eugenol during the treatment.
- Comparator Control
- Inclusion criteria: Experimental studies with control (diabetic animals) and treatment (diabetic animals treated with eugenol) groups. Exclusion criteria: Studies with absence of one of these groups.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Studies must have reported means , sample size, and mesure of variance ( standard deviation, standard error or confidence interval) for both control and treament groups. Exclusion criteria: Studies with no means, no sample size, and no measure of variance (standard deviation, standard error or confidence interval) for both control and treatment groups.
- Additional Outcome
- Study Method
- Keyword
- Animals; Eugenol; Models, Animal
- Contact
- Renner Philipe Rodrigues Carvalho [email protected]
- Organisational Affiliation
- Federal University of Viçosa https://www.ufv.br/
- Funding Source
- For this and other work, we received financial support from the Higher Education Improvement Coordination (CAPES), the National Council for Scientific and Technological Development (CNPq) and the Minas Gerais Research Support Foundation (FAPEMIG).
- Other Selection Criteria
- Exclusion: reviews, conference abstract, studies in order language than English
- Final Publication
- Paper accepted for publication. Waiting for publication.
- Same Topic Review
- Published Protocol
- Review Type
- Animal model review, Experimental animal exposure review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Completed published
- First Submission Date
- 2019-11-18
- Registration Date
- 2019-12-09
- Anticipated Start Date
- 2019-11-22
- Anticipated Completion Date
- 2020-02-29
- Title Cn
- 丁香酚的抗糖尿病作用：动物研究的Meta分析
- Title En
- Antidiabetic effect of eugenol: A meta-analysis of animal studies.
- Bilingual Status
- complete