Meta AnalysisID 2394
表没食子儿茶素没食子酸酯改善心肌缺血/再灌注损伤的临床前证据：动物实验的系统评价与Meta分析
CRD42023390971
Does Epigallocatechin gallate treatment reduce myocardial ischemia/reperfusion injury in animal myocardial ischemia/reperfusion injury models? Context and rationale Myocardial infarction is estimated to affect more than
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2394
- Evidence Id
- 10952
- Core Evidence Id
- 10952
- Source Meta Analysis Id
- 2342
- Herb2 Meta Analysis Id
- HBMA002342
- Crd Id
- CRD42023390971
- Title
- Pre-clinical Evidence of Epigallocatechin-gallate Ameliorates Myocardial Ischemia/Reperfusion injury: a Systemic Review and Meta-analysis of animal studies
- Review Question
- Does Epigallocatechin gallate treatment reduce myocardial ischemia/reperfusion injury in animal myocardial ischemia/reperfusion injury models? Context and rationale Myocardial infarction is estimated to affect more than 3 million people annually, which has caused a heavy burden on the world. Currently, there is a lack of effective drugs to treat myocardial infarction. Therefore, it is of great significance to discover effective drugs to treat myocardial infarction. Recent studies have found that epigallocatechin gallate has a potential cardioprotective effect on myocardial ischemia/refusion injury through multifaceted and diverse mechanisms. This meta-analysis was conducted to determine if epigallocatechin gallate can exhibit a protective role in myocardial I/R injury.
- Study Type Included
- Inclusion criteria: controlled studies with a separate control group. Exclusion criteria: studies without a separate control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: all animal models with myocardial I/R injury Exclusion criteria: 1. animals with co-morbidities, 2. studies in humans or in sillico studies.
- Human Disease Modelled
- Myocardial infarction.
- Intervention
- Inclusion criteria: 1. Blocking the left anterior descending branch (LAD), injecting isoprenaline (ISO), or using Langendorff perfusion to establish the myocardial I/R experimental models; 2. Epigallocatechin gallate was the only intervention, with control animals receiving placebo fluid or no treatment at all. Exclusion criteria: 1. without a control group, 2. Epigallocatechin gallate is not the only intervention.
- Comparator Control
- Inclusion criteria: vehicle-treated control animals Exclusion criteria: no treatment
- Main Outcome
- Outcome Measure
- Inclusion criteria: Infarct size, LVEF, LVDP, LDH, and CK-MB. Exclusion criteria: no relevant outcomes were reported.
- Additional Outcome
- Study Method
- Keyword
- Animals; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Reperfusion; epigallocatechin gallate; gallocatechol
- Contact
- Yifan Zeng [email protected]
- Organisational Affiliation
- Department of Cardiovascular Surgery, the Second Xiangya Hospital, Central South University https://www.xyeyy.com/
- Funding Source
- This study was supported by the National Natural Science Foundation of China, and the Hunan Provincial Natural Science Foundation of China. Grant number(s) No.81903663 and No. 2020JJ5944.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-01-11
- Registration Date
- 2023-01-24
- Anticipated Start Date
- 2023-01-21
- Anticipated Completion Date
- 2023-05-31
- Title Cn
- 表没食子儿茶素没食子酸酯改善心肌缺血/再灌注损伤的临床前证据：动物实验的系统评价与Meta分析
- Title En
- Pre-clinical Evidence of Epigallocatechin-gallate Ameliorates Myocardial Ischemia/Reperfusion injury: a Systemic Review and Meta-analysis of animal studies
- Bilingual Status
- complete