Meta AnalysisID 2392
表没食子儿茶素没食子酸酯对膀胱癌的治疗效果及作用机制：一项系统评价
CRD42021289342
Is epigallocatechin gallate effective supplementation in bladder cancer disease?
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Record Fields
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- Meta Analysis Id
- 2392
- Evidence Id
- 10950
- Core Evidence Id
- 10950
- Source Meta Analysis Id
- 2340
- Herb2 Meta Analysis Id
- HBMA002340
- Crd Id
- CRD42021289342
- Title
- Therapeutic effects and mechanisms of action of epigallocatechin gallate on bladder cancer: A systematic review
- Review Question
- Is epigallocatechin gallate effective supplementation in bladder cancer disease?
- Study Type Included
- All of the clinical trials and animal and in-vitro models.
- Condition Being Studied
- Bladder cancer is a common urinary cancer worldwide and its high rate of recurrence results in poor clinical outcomes. Patients with high‑risk bladder tumors have approximately a 50% chance of recurrence if treated with surgery alone. Muscle‑invasive bladder cancer and non‑muscle‑invasive bladder cancer. After surgical resection, the current standard treatment is cisplatin‑based chemotherapy. The signaling pathway is critical for the development, initiation, and progression of bladder cancer, and promotes bladder tumorigenicity and stemness by activating epithelial‑to‑mesenchymal transition. Shh signaling pathway activity shows distinct spatial and temporal distribution during bladder development. Epigallocatechin‑3‑gallate (EGCG) is an abundant polyphenol from green tea and plays antitumor roles in various cancers including bladder cancer. EGCG downregulates nuclear factor‑κB and matrix metalloproteinase‑9 to inhibit bladder cancer SW780 cell proliferation and migration both in vitro and in vivo. In addition, EGCG also suppresses bladder cancer cell metastasis via the PI3K/AKT signaling pathway.
- Participant
- bladder cancer disease
- Animal
- Human Disease Modelled
- Intervention
- Epigallocatechin gallate
- Comparator Control
- control
- Main Outcome
- signaling pathway, inflammation, oxidative stress Measures of effect signaling pathway, inflammation, oxidative stress, side effects, toxicity
- Outcome Measure
- Additional Outcome
- regulate signaling pathway, antiinflammation, antioxidative stress
- Study Method
- Systematic review
- Keyword
- Catechin; Humans; Urinary Bladder Neoplasms; epigallocatechin gallate
- Contact
- Arash Karimi [email protected]
- Organisational Affiliation
- Tabriz University of Medical Sciences, Tabriz, Iran.
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-11-04
- Registration Date
- 2021-12-05
- Anticipated Start Date
- 2021-10-25
- Anticipated Completion Date
- 2022-01-30
- Title Cn
- 表没食子儿茶素没食子酸酯对膀胱癌的治疗效果及作用机制：一项系统评价
- Title En
- Therapeutic effects and mechanisms of action of epigallocatechin gallate on bladder cancer: A systematic review
- Bilingual Status
- complete