Meta AnalysisID 2389
(–)-表儿茶素摄入对心血管代谢参数的影响——随机对照干预研究的系统评价
CRD42021293038
Does an oral intake of pure (–)-epicatechin beneficially affect cardiometabolic parameters in humans?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2389
- Evidence Id
- 10947
- Core Evidence Id
- 10947
- Source Meta Analysis Id
- 2337
- Herb2 Meta Analysis Id
- HBMA002337
- Crd Id
- CRD42021293038
- Title
- Effect of (–)-epicatechin intake on cardiometabolic parameters – a systematic review of randomized controlled intervention studies
- Review Question
- Does an oral intake of pure (–)-epicatechin beneficially affect cardiometabolic parameters in humans?
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Healthy and/or suffering from cardiometabolic diseases (incl. pre-stage)
- Participant
- Inclusion: Healthy participants and/or overweight/obese participants, and/or participants with cardiometabolic disorders, including (pre)hypertension, hypertriglyceridemia, dysglycemia, impaired endothelial function, (pre)diabetes, atherosclerosis, coronary heart diseases. Exclusion: cardiometabolic diseases caused by another underlying disease or condition (e.g., medication) if clearly stated in the publication, other diseases such as cancer), healthy participants in particular life conditions (e.g., pregnancy).
- Animal
- Human Disease Modelled
- Intervention
- Inclusion criteria: Interventions with pure (–)-epicatechin provided orally. Exclusion criteria: Intervention with other flavonoids than (–)-epicatechin (e.g., (+)-epicatechin, quercetin), not pure (–)-epicatechin (e.g., intake together with other flavonoids or compounds (e.g., by cocoa, dark chocolate, or green tea)), (–)-epicatechin not administered orally.
- Comparator Control
- Control treatment: using an (–)-epicatechin-free placebo if (–)-epicatechin was provided as supplement (e.g., capsules, tablets) or an (–)-epicatechin-free control treatment.
- Main Outcome
- Glucose metabolism (e.g., glucose, insulin, HOMA-IR, HbA1c, fructosamine); lipid metabolism (e.g., triglycerides (TG), total cholesterol (TC), LDL-C, HDL-C, TG/HDL-C ratio); vascular function (e.g., blood pressure, FMD, pulse wave velocity)
- Outcome Measure
- Additional Outcome
- Antioxidant status/oxidative stress (e.g., oxidized LDL) and inflammation biomarkers (e.g., CRP)
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Cacao; Cardiovascular Diseases; Catechin; Humans
- Contact
- Sabine Ellinger [email protected]
- Organisational Affiliation
- University of Bonn
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Germany
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-11-23
- Registration Date
- 2021-12-24
- Anticipated Start Date
- 2021-12-01
- Anticipated Completion Date
- 2022-05-31
- Title Cn
- (–)-表儿茶素摄入对心血管代谢参数的影响——随机对照干预研究的系统评价
- Title En
- Effect of (–)-epicatechin intake on cardiometabolic parameters – a systematic review of randomized controlled intervention studies
- Bilingual Status
- complete