Meta AnalysisID 2351
蔓越莓、D-甘露糖和非甾体抗炎药预防或治疗女性非复杂性尿路感染的临床试验结果：系统评价
CRD42021297037
What are the human clinical trial outcomes of different nonantibiotic alternatives including: 1. cranberry 2. D-mannose 3. NSAIDs in preventing or treating uncomplicated UTIs in adult, non-pregnant women?
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Record Fields
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- Meta Analysis Id
- 2351
- Evidence Id
- 10909
- Core Evidence Id
- 10909
- Source Meta Analysis Id
- 2298
- Herb2 Meta Analysis Id
- HBMA002298
- Crd Id
- CRD42021297037
- Title
- The Clinical Trial Outcomes Of Cranberry, D-mannose And NSAIDs In The Prevention Or Treatment Of Uncomplicated Urinary Tract Infections In Women: A Systematic Review
- Review Question
- What are the human clinical trial outcomes of different nonantibiotic alternatives including: 1. cranberry 2. D-mannose 3. NSAIDs in preventing or treating uncomplicated UTIs in adult, non-pregnant women?
- Study Type Included
- Just needs to be a human clinical trial in women, there are no restrictions to the type of study. This is because we do not want to limit the scope of trials.
- Condition Being Studied
- Urinary tract Infections (UTIs) are most common in women, comprising nearly 25% of all infections. Approximately 50 to 60% of women will report a UTI at least once in their lifetime, with one in three women experiencing a symptomatic UTI treated with antibiotics by age 24. Of these women, 20–40% will experience recurrent UTI (r-UTI). To treat UTIs, antibiotics are typically prescribed for uncomplicated bacterial cystitis. However, in many countries antibiotic resistance has significantly increased towards these first-line antimicrobial drugs and developed multi- and pan-drug resistant strains. Hence, there is a need to investigate other nonantibiotic alternatives for preventing or treating UTIs. This review hopes to provide evidence from human clinical trials of whether nonantibiotic treatments were effective in preventing or treating uncomplicated UTIs in adult, non-pregnant women.
- Participant
- Inclusion: Adult, non-pregnant women (<u>></u> 18 years old) with an uncomplicated UTI Exclusion: Pregnant women, children, men with a UTI
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: Cranberry (any cranberry formulations in a capsule or drink form) , D-mannose (any D-mannose formulations in a capsule or drink form) or non-steroidal anti-inflammatory drugs (NSAIDs)
- Comparator Control
- Must compare a cranberry, D-mannose or NSAID to a control (placebo, lower dosage of nonantibiotic treatment, no intervention etc.)
- Main Outcome
- Primary outcomes assessed include: 1. The number of symptomatic UTIs obtained during treatment period 2. Symptom resolution Secondary outcomes assessed include: 1. Time to first recurrence 2. Change in antibiotic consumption Measures of effect Number needed to prevent or treat UTIs
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Systematic review
- Keyword
- Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Mannose; Phytotherapy; Urinary Tract Infections; Vaccinium macrocarpon
- Contact
- Jenane Konesan [email protected]
- Organisational Affiliation
- UNSW
- Funding Source
- Not applicable Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- not applicable
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-12-08
- Registration Date
- 2021-12-08
- Anticipated Start Date
- 2021-08-31
- Anticipated Completion Date
- 2022-03-31
- Title Cn
- 蔓越莓、D-甘露糖和非甾体抗炎药预防或治疗女性非复杂性尿路感染的临床试验结果：系统评价
- Title En
- The Clinical Trial Outcomes Of Cranberry, D-mannose And NSAIDs In The Prevention Or Treatment Of Uncomplicated Urinary Tract Infections In Women: A Systematic Review
- Bilingual Status
- complete