Meta AnalysisID 2348
外用二苯环丙烯酮治疗途中转移及皮肤黑色素瘤转移的疗效：一项系统评价与Meta分析
CRD42022367048
What is the efficacy of diphencyprone in treating in-transit or other cutaneous melanoma metastases?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2348
- Evidence Id
- 10906
- Core Evidence Id
- 10906
- Source Meta Analysis Id
- 2295
- Herb2 Meta Analysis Id
- HBMA002295
- Crd Id
- CRD42022367048
- Title
- Efficacy of topical diphencyprone for in-transit and cutaneous melanoma metastases: A systematic review and meta-analysis
- Review Question
- What is the efficacy of diphencyprone in treating in-transit or other cutaneous melanoma metastases?
- Study Type Included
- Inclusion criteria included randomised control trials (RCTs), single arm observational studies, or case series (ࣙࣙ≥5 patients); adult patients with cutaneously metastatic melanoma; the use of topical DCP and reporting of RR in treated lesions. Conference papers, abstracts only, review articles, editorials, and studies of combination therapy with other treatment modalities will be excluded.
- Condition Being Studied
- Cutaneously metastatic melanoma, defined as ‘satellite’ when within 2cm of the primary tumour and ‘in-transit’ when between 2cm from the tumour and the draining nodal basin.
- Participant
- Patients with satellite or in-transit metastases of cutaneous melanoma who are 18 years of age or older.
- Animal
- Human Disease Modelled
- Intervention
- Topical diphencyprone (DCP)
- Comparator Control
- Historical outcomes reported for other treatment modalities for ITMs such as intralesional immunotherapy (IL-2 or TVEC), isolated limb infusion, electrochemotherapy and systemic immune checkpoint inhibition.
- Main Outcome
- Response rate (RR) of treated lesions, including complete and partial responses (CR and PR, respectively).
- Outcome Measure
- Additional Outcome
- Progression free survival (PFS); median overall survival (OS); adverse event rate (AER).
- Study Method
- Intervention, Systematic review
- Keyword
- Cyclopropanes; Humans; Immunotherapy; Melanoma; Skin Neoplasms; diphenylcyclopropenone
- Contact
- James Pham [email protected]
- Organisational Affiliation
- St Vincent's Hospital, Sydney
- Funding Source
- Nil
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-10-13
- Registration Date
- 2022-10-24
- Anticipated Start Date
- 2022-10-17
- Anticipated Completion Date
- 2022-11-30
- Title Cn
- 外用二苯环丙烯酮治疗途中转移及皮肤黑色素瘤转移的疗效：一项系统评价与Meta分析
- Title En
- Efficacy of topical diphencyprone for in-transit and cutaneous melanoma metastases: A systematic review and meta-analysis
- Bilingual Status
- complete