Meta AnalysisID 2326
双氢青蒿素-哌喹重复剂量用于妊娠期疟疾间歇性预防治疗的安全性与耐受性：随机对照试验的系统评价与Meta分析
CRD42022310041
Are repeated doses of dihydroartemisinin-piperaquine safe and tolerable in intermittent preventive treatment of malaria in pregnancy?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2326
- Evidence Id
- 10884
- Core Evidence Id
- 10884
- Source Meta Analysis Id
- 2275
- Herb2 Meta Analysis Id
- HBMA002275
- Crd Id
- CRD42022310041
- Title
- Safety and Tolerability of Repeated Doses of Dihydroartemisinin-Piperaquine for Intermittent Preventive Treatment of Malaria in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Review Question
- Are repeated doses of dihydroartemisinin-piperaquine safe and tolerable in intermittent preventive treatment of malaria in pregnancy?
- Study Type Included
- Randomised Controlled Trials
- Condition Being Studied
- Malaria in pregnancy
- Participant
- Pregnant women and adolescents in their second and third trimester
- Animal
- Human Disease Modelled
- Intervention
- Dihydroartemisinin-piperaquine Tablets administered monthly
- Comparator Control
- Recommended standard treatment for IPTp
- Main Outcome
- Change in QTc interval, Incidence of serious adverse events Incidence of grade 3 or 4 adverse events possibly related to study drugs Prevalence of vomiting after study drug administration. Measures of effect Risk ratio for SAEs, grade 3 or 4 AEs possibly related to study drug and vomiting after study drug administration. Mean change for change in QTc interval
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Female; Humans; Malaria; Pregnancy; Quinolines; Randomized Controlled Trials as Topic; artenimol; piperaquine
- Contact
- Esther Muthoka [email protected]
- Organisational Affiliation
- Center for Innovative Drug Development and Therapeutic Trials for Africa(CDT-Africa) www.cdt-africa.org
- Funding Source
- Center for Innovative Drug Development and Therapeutic Trials for Africa(CDT-Africa)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Ethiopia
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-02-11
- Registration Date
- 2022-03-14
- Anticipated Start Date
- 2021-08-11
- Anticipated Completion Date
- 2022-03-31
- Title Cn
- 双氢青蒿素-哌喹重复剂量用于妊娠期疟疾间歇性预防治疗的安全性与耐受性：随机对照试验的系统评价与Meta分析
- Title En
- Safety and Tolerability of Repeated Doses of Dihydroartemisinin-Piperaquine for Intermittent Preventive Treatment of Malaria in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Bilingual Status
- complete