Meta AnalysisID 2325
双氢青蒿素-哌喹对比蒿甲醚-本芴醇治疗非洲儿童无并发症恶性疟的疗效与安全性：随机对照试验的系统评价与Meta分析
CRD42020200337
What is the efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in African infants and children? What is the safety of dihydroartemisinin-piperaqui
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Record Fields
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- Meta Analysis Id
- 2325
- Evidence Id
- 10883
- Core Evidence Id
- 10883
- Source Meta Analysis Id
- 2274
- Herb2 Meta Analysis Id
- HBMA002274
- Crd Id
- CRD42020200337
- Title
- Efficacy and safety of dihydroartemisinin Piperaquine versus artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in African children. Systematic review and meta-analysis of randomized control trials.
- Review Question
- What is the efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in African infants and children? What is the safety of dihydroartemisinin-piperaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in African infants and children?
- Study Type Included
- Randomized controlled trials
- Condition Being Studied
- Uncomplicated falciparum malaria
- Participant
- Children having uncomplicated falciparum malaria residing in Africa, regardless of gender will be included.
- Animal
- Human Disease Modelled
- Intervention
- A course of dihydroartemisinin-piperaquine given as multiple doses over three days.
- Comparator Control
- A three-day course of artemether-lumefantrine. Different dosages of an antimalarial regimen will be considered as individual treatments.
- Main Outcome
- The treatment outcome will be determined according to the classification of WHO Methods and techniques for clinical trials on antimalarial drug efficacy: genotyping to identify parasite populations will be classified as; Early treatment failure (ETF), Late clinical failure (LCF), Late parasitological failure (LPF), and Adequate clinical and parasitological response (ACPR). Measures of effect For dichotomous outcomes, we will record the number of participants experiencing the event and the number of participants in each treatment group, and our effect measure will be a relative risk.
- Outcome Measure
- Additional Outcome
- Additional outcomes: such as adverse events, serious adverse events (life-threatening, causing admission to hospital, or discontinuation of treatment), and Change in hemoglobin from baseline (minimum 28 days and 42 days follow-up). will be included. Measures of effect For dichotomous outcomes, we will record the number of participants experiencing the event and the number of participants in each treatment group, and our effect measure will be a relative risk. For continuous outcomes, we will extract the arithmetic means and standard deviations for each treatment group together with the numbers of participants in each group, and our effect measure will be the mean difference.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Humans; Infant; Malaria, Falciparum; Quinolines; dihydroartemisinin; piperaquine
- Contact
- Dawit Getachew Assefa [email protected]
- Organisational Affiliation
- Dilla University http://www.du.edu.et/
- Funding Source
- Addis Ababa University, College of Health Science, Department of CDT Africa
- Other Selection Criteria
- Final Publication
- • Assefa, D.G., Yismaw, G. & Makonnen, E. Efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria among children in Africa: a systematic review and meta-analysis of randomized control trials. Malar J 20, 340 (2021). https://doi.org/10.1186/s12936-021-03873-1 • Assefa DG, Yesmaw G, Makonnen E. Comparative effect of dihydroartemisinin-piperaquine versus artemether-lumefantrine on gametocyte clearance and hemoglobin recovery in children with uncomplicated Plasmodium falciparum malaria in Africa: a systematic review and meta-analysis of randomized control trials. Int J Infect Dis. 2021 Oct 12:S1201-9712(21)00799-2. doi: 10.1016/j.ijid.2021.10.013. Epub ahead of print. PMID: 34653658. https://doi.org/10.1186/s12936-021-03873-1
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Ethiopia
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-07-22
- Registration Date
- 2020-08-22
- Anticipated Start Date
- 2020-11-30
- Anticipated Completion Date
- 2021-06-01
- Title Cn
- 双氢青蒿素-哌喹对比蒿甲醚-本芴醇治疗非洲儿童无并发症恶性疟的疗效与安全性：随机对照试验的系统评价与Meta分析
- Title En
- Efficacy and safety of dihydroartemisinin Piperaquine versus artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in African children. Systematic review and meta-analysis of randomized control trials.
- Bilingual Status
- complete