Meta AnalysisID 2322
双氢青蒿素-哌喹重复疗程用于妊娠期和儿童疟疾化学预防的心脏影响：一项个体患者数据Meta分析
CRD42020175259
Do cardiac adverse events or QT prolongation increase with successive doses of DP given malaria chemoprevention?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2322
- Evidence Id
- 10880
- Core Evidence Id
- 10880
- Source Meta Analysis Id
- 2271
- Herb2 Meta Analysis Id
- HBMA002271
- Crd Id
- CRD42020175259
- Title
- Cardiac effects of repeat courses of dihydroartemisinin-piperaquine for malaria chemoprevention in pregnancy and children: An individual patient data meta-analysis
- Review Question
- Do cardiac adverse events or QT prolongation increase with successive doses of DP given malaria chemoprevention?
- Study Type Included
- Clinical studies with repeated dosing of piperaquine provided for malaria chemoprevention that include ECG results
- Condition Being Studied
- Malaria
- Participant
- Children, adults, or pregnant women living in malaria
- Animal
- Human Disease Modelled
- Intervention
- prophylaxis or malaria chemoprevention or intermittent preventive treatment with dihydroartemisinin-piperaquine
- Comparator Control
- dose response
- Main Outcome
- mean QTc prolongation Measures of effect Timing and effect measures: QTC prolongation will be assessed at the time of the maximum concentrations of piperaquine which occurs 4 to 6 hours following the third DP dose for course administered Cardiac events: measured within 30 days of piperaquine dosing
- Outcome Measure
- Additional Outcome
- QTc> 480 ms; QTc> 500 ms Delta QTc > 60 ms Cardiac adverse events (seizures, syncope, arrhythmias, and sudden death) Measures of effect QTc prolongation will be assessed at the time of the maximum drug concentrations of piperaquine which occurs 4 to 6 hours following the third DP dose for each course administered
- Study Method
- Individual patient data (IPD) meta-analysis, Intervention, Systematic review
- Keyword
- Chemoprevention; Child; Female; Humans; Malaria; Pregnancy; Quinolines; artenimol; piperaquine
- Contact
- Julie Gutman [email protected]
- Organisational Affiliation
- CDC
- Funding Source
- WWARN Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span>
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England, Kenya, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-03-19
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-03-23
- Anticipated Completion Date
- 2020-12-31
- Title Cn
- 双氢青蒿素-哌喹重复疗程用于妊娠期和儿童疟疾化学预防的心脏影响：一项个体患者数据Meta分析
- Title En
- Cardiac effects of repeat courses of dihydroartemisinin-piperaquine for malaria chemoprevention in pregnancy and children: An individual patient data meta-analysis
- Bilingual Status
- complete