Meta AnalysisID 2321
双氢青蒿素-哌喹对比磺胺多辛-乙胺嘧啶用于妊娠期间间歇性预防恶性疟原虫疟疾的疗效与安全性：随机对照试验的Meta分析
CRD42020165435
How does Dihydroartemisinin-piperaquine fair in intermittent preventive treatment of falciparum malaria during pregnancy compared to sulfadoxine-pyrimethamine?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2321
- Evidence Id
- 10879
- Core Evidence Id
- 10879
- Source Meta Analysis Id
- 2270
- Herb2 Meta Analysis Id
- HBMA002270
- Crd Id
- CRD42020165435
- Title
- Dihydroartemisinin-piperaquine versus Sulfadoxine-pyrimethamine efficacy and safety for intermittent preventive treatment of Plasmodium falciparum malaria during pregnancy: meta-analysis of randomized control trials
- Review Question
- How does Dihydroartemisinin-piperaquine fair in intermittent preventive treatment of falciparum malaria during pregnancy compared to sulfadoxine-pyrimethamine?
- Study Type Included
- Randomize controlled trials
- Condition Being Studied
- Malaria. Peripheral or placental parasitaemia
- Participant
- Inclusion: Expectant mothers diagnosed with falciparum malaria by microscopy or rapid diagnostic tests (RDTs) Exclusion: Adolescents (under 18 years of age) and elderly people.
- Animal
- Human Disease Modelled
- Intervention
- Dihydroartemisinin-piperaquine or sulfadoxine-pyrimethamine
- Comparator Control
- Dihydroartemisinin-piperaquine or sulfadoxine-pyrimethamine
- Main Outcome
- Malaria infection at delivery, defined as peripheral or placental parasitaemia detected by placental histology, microscopy, or rapid diagnostic tests (RDTs) Measures of effect At delivery
- Outcome Measure
- Additional Outcome
- 1. Malaria infection and clinical malaria during pregnancy, defined as fever or recent history of fever in the presence of malaria parasites. 2. Anaemia (haemoglobin <110 g/L) during pregnancy or at delivery 3.Prevalence of adverse newborn morbidity at birth, constituting either low birthweight (<2500 g), preterm delivery (<37 weeks’ gestation), or small for gestational age (<10th percentile relative to an external growth reference) Measures of effect During 2nd and 3rd trimester
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Female; Humans; Malaria, Falciparum; Pregnancy; Sulfadoxine; artenimol; fanasil, pyrimethamine drug combination; piperaquine
- Contact
- Muturi Njokah [email protected]
- Organisational Affiliation
- Kenya Medical Research Institute https://www.kemri.org/
- Funding Source
- Review not funded
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Kenya
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-01-14
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2020-01-14
- Anticipated Completion Date
- 2020-02-17
- Title Cn
- 双氢青蒿素-哌喹对比磺胺多辛-乙胺嘧啶用于妊娠期间间歇性预防恶性疟原虫疟疾的疗效与安全性：随机对照试验的Meta分析
- Title En
- Dihydroartemisinin-piperaquine versus Sulfadoxine-pyrimethamine efficacy and safety for intermittent preventive treatment of Plasmodium falciparum malaria during pregnancy: meta-analysis of randomized control trials
- Bilingual Status
- complete