Meta AnalysisID 2305
产前与产后暴露于邻苯二甲酸二(2-乙基己基)酯和邻苯二甲酸二丁酯与体格生长：一项系统评价与Meta分析
CRD42021235007
Does the prenatal and postnatal exposure of phthalates affect the physical growth of children?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2305
- Evidence Id
- 10863
- Core Evidence Id
- 10863
- Source Meta Analysis Id
- 2253
- Herb2 Meta Analysis Id
- HBMA002253
- Crd Id
- CRD42021235007
- Title
- Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and dibutyl phthalate and physical growth: A systematic review and meta-analysis
- Review Question
- Does the prenatal and postnatal exposure of phthalates affect the physical growth of children?
- Study Type Included
- We will only include observational studies cohort, case-control, or cross-sectional design.
- Condition Being Studied
- Phthalate is a well-known endocrine-disrupting chemical that has anti-androgenic effects. However, studies for the association between phthalate and obesity has reported inconsistent results. Although a systematic review and meta-analysis performed by Mohsen et al. was published in 2019, it has a methodological fault. Furthermore, the systematic review for the association between phthalate and other physical growth outcomes such as height or skeletal muscle mass has yet been studied.
- Participant
- Inclusion criteria were: (1) cohort, case-control, or cross-sectional design; (2) reported effect estimates, such as beta estimates (β), with 95% confidence interval (CI), or outcome values that allowed for effect to be estimated by calculations in a 2×2 cell table. Exclusion criteria were (1) reported irrelevant outcomes; (2) absence of effect estimates or an inability to calculate the size of the association; (3) letter, commentary, or review article; (4) study population identical to that of a later study (we included only the latest publication after a review of the full text); (5) not in English; and (6) nonhuman subjects.
- Animal
- Human Disease Modelled
- Intervention
- Exposures were defined as levels of di-(2-ethylhexyl) phthalate and dibutyl phthalate metabolites in urine of pregnant women (prenatal) and in urine of children (postnatal).
- Comparator Control
- No intervention group
- Main Outcome
- BMI Z-score Measures of effect Beta estimates (β), with 95% confidence interval (CI)
- Outcome Measure
- Additional Outcome
- Height, body fat percentage, lean mass percentage, fat mass index, skeletal muscle index Measures of effect Beta estimates (β), with 95% confidence interval (CI)
- Study Method
- Epidemiologic, Systematic review
- Keyword
- Dibutyl Phthalate; Diethylhexyl Phthalate; Female; Humans; Phthalic Acids; Pregnancy; phthalic acid
- Contact
- Dong-Wook Lee [email protected]
- Organisational Affiliation
- Seoul National University prevmed.snu.ac.kr
- Funding Source
- not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- South Korea
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-02-03
- Registration Date
- 2021-03-05
- Anticipated Start Date
- 2021-02-15
- Anticipated Completion Date
- 2021-05-15
- Title Cn
- 产前与产后暴露于邻苯二甲酸二(2-乙基己基)酯和邻苯二甲酸二丁酯与体格生长：一项系统评价与Meta分析
- Title En
- Prenatal and postnatal exposure to di-(2-ethylhexyl) phthalate and dibutyl phthalate and physical growth: A systematic review and meta-analysis
- Bilingual Status
- complete