Meta AnalysisID 2303
血清β-D-葡聚糖与半乳甘露聚糖抗原检测对儿童侵袭性真菌感染诊断价值的比较：一项系统评价与Meta分析
CRD42019119114
Is Serum Beta-D-Glucan Assay better than Galactomannan Antigen Assay for diagnosing invasive fungal infections in children?
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2303
- Evidence Id
- 10861
- Core Evidence Id
- 10861
- Source Meta Analysis Id
- 2251
- Herb2 Meta Analysis Id
- HBMA002251
- Crd Id
- CRD42019119114
- Title
- Comparison of Serum Beta-D-Glucan and Galactomannan Antigen Assay for the diagnosis of invasive fungal infections in children: a systematic review and meta-analysis
- Review Question
- Is Serum Beta-D-Glucan Assay better than Galactomannan Antigen Assay for diagnosing invasive fungal infections in children?
- Study Type Included
- Diagnostic Cross sectional studies will be included.
- Condition Being Studied
- Due to the rising number of immunocompromised children at risk of developing invasive fungal infections (IFI), this condition continues to be associated with considerable morbidity, mortality and financial burden. Children with hematologic malignancies, congenital or acquired immunodeficiency, those receiving immunosupressants, premature neonates and children admitted to intensive care units are the major subsets at risk of developing IFIs. The two most common pediatric IFIs are invasive candidiasis (IC) and invasive aspergillosis (IA). Despite the availability of new antifungal agents, their substantially different pharmacokinetics in children and adults mandates the use of age-adapted management approaches to treat IFI in pediatric population. One of the critical pre-requisites for the appropriate initiation of treatment for IFI is its prompt and accurate diagnosis. Accurate diagnosis will also prevent the unnecessary use of potentially toxic and expensive antifungal drugs in patients with clinically suspected IFI. Conventional diagnostic modalities of culture and microscopy are limited by a low sensitivity, long turnaround time, the need for invasive sampling and the frequent contamination of fungal cultures. IFI diagnosis is even more challenging in children since clinical signs and symptoms are often non specific and performing invasive sampling is a point of contention.
- Participant
- Inclusion criteria: All children <18 years of age with the suspicion of Invasive Fungal Infections(IFIs). Children at high risk of IFIs are those suffering from primary or secondary immuno-deficiencies , Haematological malignancies, Prematurity or prolonged illness with intensive care interventions will be included.
- Animal
- Human Disease Modelled
- Intervention
- The Studies in which both B-D-Glucan and Galactomannan Antigen assay have been used to diagnose IFI will be included. The studies in which only one of the two tests has been used will be excluded.
- Comparator Control
- The reference test for diagnosing IFI should be as per the EORTC/MSG guidelines which uses Microscopic analysis or culture from a sterile site, Blood culture and yielding mould or fungus for a positive diagnosis.
- Main Outcome
- Primary outcomes will include Sensitivity and Specificity of Serum Beta-D-Glucan and Galactomannan Antigen assay for the diagnosis of IFIs in children with the EORTC/MSG criteria for Proven IFIs used as the gold standard. The Data for sensitivity and specificity will be pooled to ascertain which of the two tests is better or whether both should be combined to achieve the maximum diagnostic accuracy. Measures of effect Sensitivity and specificity as percentage. Diagnostic Odds Ratios
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Diagnostic, Systematic review
- Keyword
- Child; Humans; Immunologic Tests; Invasive Fungal Infections; Mannans; beta-Glucans; galactomannan
- Contact
- Shreya Singh [email protected]
- Organisational Affiliation
- Postgraduate Institute of Medical Education and Research
- Funding Source
- Other Selection Criteria
- Final Publication
- Shreya Singh, Manvi Singh, Nipun Verma, Minakshi Sharma, Pranita Pradhan, Anil Chauhan, Nishant Jaiswal, Arunaloke Chakrabarti, Meenu Singh, Comparative accuracy of 1, 3 beta-D glucan and galactomannan for diagnosis of invasive fungal infections in pediatric patients: a systematic review with meta-analysis, Medical Mycology, , myaa038, https://doi.org/10.1093/mmy/myaa038 https://academic.oup.com/mmy/advance-article-abstract/doi/10.1093/mmy/myaa038/5843679?redirectedFrom=fulltext
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Completed published
- First Submission Date
- 2018-12-08
- Registration Date
- 2019-01-29
- Anticipated Start Date
- 2018-11-01
- Anticipated Completion Date
- 2019-06-30
- Title Cn
- 血清β-D-葡聚糖与半乳甘露聚糖抗原检测对儿童侵袭性真菌感染诊断价值的比较：一项系统评价与Meta分析
- Title En
- Comparison of Serum Beta-D-Glucan and Galactomannan Antigen Assay for the diagnosis of invasive fungal infections in children: a systematic review and meta-analysis
- Bilingual Status
- complete