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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2294
- Evidence Id
- 10852
- Core Evidence Id
- 10852
- Source Meta Analysis Id
- 2241
- Herb2 Meta Analysis Id
- HBMA002241
- Crd Id
- CRD42020163015
- Title
- Utility of pleural amylase value as anastomotic predictor fistula after esophagectomy in patients with esophageal neoplasms: Systematic review and meta-analysis
- Review Question
- Study Type Included
- Cross-seccional, single-gate design, two-gate desings
- Condition Being Studied
- Esophageal resection is associated with major operative morbidity with perioperative mortality in the National Inpatient Sample of 11%. High-volume centers have demonstrated improvement in perioperative morbidity and mortality with protocoled systems, which include team-based approaches that quickly identify and manage postoperative complications. Anastomotic leak following esophageal resection occurs in up to 30% of patients and remains one of the most significant postoperative complications, correlating with shortened cancer-specific survival.
- Participant
- Inclusion: Adult patients with esophageal neoplasia (malignant and benign, including mesenchymal tumors, neuroendocrine cancers)
- Animal
- Human Disease Modelled
- Intervention
- Various tissues can produce the enzyme amylase, being the most important the pancreas, but also including salivary glands, small intestines, ovaries, adipose tissue and skeletal muscles. Amylase can be measured by immunochemical assays, usually with monoclonal antibodies (Maeda 2008; Mifflin 1985). Drain fluid amylase that posses na amount greater than three times the upper normal serum value is considered to be abnormal (Bassi 2005). Normal serum amylase can vary between laboratories but is usually between 100 IU/L and 300 IU/ L (Vissers 1999)
- Comparator Control
- (reference standard) A gold standard for diagnosin leakage has not yet been established. If this complication is suspected, it is crucial that further medical tests are administered directly as any delay can significantly affect the patient’s prognosis. Various modalities to diagnose anastomotic leaks have been proposed: Clinical signs, drain fluid, and blood tests, Upper endoscopy, Contrast esophagogram, Computed tomography (CT) scan (with or without oral contrast).
- Main Outcome
- Serial amylase levels for anastomotic leaks following esophagectomies by neoplasms may be accurate, safe, and inexpensive, as shown in some studies. Elimination of barium swallows and computed tomography to assess anastomotic integrity may decrease the risks of aspiration as well as associated postoperative pulmonary insufficiency. Severe amylase levels may be the preferred method for detecting anastomotic leak after esophagectomy. Measures of effect Effect measures expressed as reason: These measures can also be expressed as prevalence ratios, odds ratios (RO) and incidence density ratios. In addition, measures will be Receiver Operating Characteristic (ROC) curve analysis is a powerful tool for measuring and specifying index test performance.
- Outcome Measure
- Additional Outcome
- Not applicable Measures of effect Not applicable
- Study Method
- Cost effectiveness, Diagnostic, Meta-analysis, Systematic review
- Keyword
- Humans
- Contact
- MELISSA YOSHIURA MACENA [email protected]
- Organisational Affiliation
- Guilherme Álvaro Hospital [email protected]
- Funding Source
- No funding sources/sponsors.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Search in databases, no similar analysis found
- Published Protocol
- https://www.crd.york.ac.uk/PROSPEROFILES/163015_PROTOCOL_20191219.pdf
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-12-19
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2019-11-01
- Anticipated Completion Date
- 2020-02-01
- Title Cn
- 食管肿瘤患者食管切除术后胸水淀粉酶值预测吻合口瘘的价值：系统评价与Meta分析
- Title En
- Utility of pleural amylase value as anastomotic predictor fistula after esophagectomy in patients with esophageal neoplasms: Systematic review and meta-analysis
- Bilingual Status
- complete