Meta AnalysisID 2293
血清淀粉酶预测急性百草枯中毒后死亡率：一项Meta分析
CRD42018106263
This meta-analysis aimed to explore the effects of serum amylase as a predictor of mortality in patients with paraquat (PQ) poisoning.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2293
- Evidence Id
- 10851
- Core Evidence Id
- 10851
- Source Meta Analysis Id
- 2240
- Herb2 Meta Analysis Id
- HBMA002240
- Crd Id
- CRD42018106263
- Title
- Serum amylase in predicting mortality after acute paraquat poisoning: a meta-analysis
- Review Question
- This meta-analysis aimed to explore the effects of serum amylase as a predictor of mortality in patients with paraquat (PQ) poisoning.
- Study Type Included
- Studies were included if they met the following criteria: all prospective and retrospective full-text articles comparing the diagnostic performance of serum amylase with prognosis in PQ poisoning patients; all the subjects included in the study been given a definitive diagnosis; and serum amylase are available to calculate odds ratio (OR) and its 95% confidence interval (CI). Studies were excluded due to the following reasons: duplicated or overlapped studies; abstracts, comments, case reports, reviews, meta-analyses, and conference papers.
- Condition Being Studied
- Paraquat (PQ, 1, 1′-dimethyl-4, 4′-bipyridinium dichloride) is a quaternary nitrogen herbicide used worldwide that exerts strong toxic effects on humans and animals. Being inexpensive and easily accessible, it has become the herbicide with the highest acute poisoning mortality rate. Numerous treatment strategies for managing poisoning have been proposed, including extracorporeal elimination, immunosuppressants, and antioxidants, but the mortality rate remains high even in centers that employ these treatments. If not treated in time, PQ accumulation in the body leads to fulminant organ failure, including pulmonary edema, cardiac, kidney, and hepatic failure. Therefore, confirming the PQ-poisoning diagnosis and risk assessment in a timely manner is particularly important. Pancreatic enzymes were found to be elevated in patients with severe poisoning and pancreatitis was observed at autopsy of PQ-poisoned patients. Recently, serum amylase was been used to predict the prognosis and mortality of patients with PQ poisoning. However, as to whether serum amylase possess adequate prognostic accuracy for PQ poisoning patients. Therefore, we conducted a meta-analysis to evaluate the value of arterial lactate as a predictor of mortality in patients with PQ poisoning.
- Participant
- Patients with PQ poisoning.
- Animal
- Human Disease Modelled
- Intervention
- this review will investigate the use of serum amylase in predicting mortality after paraquat poisoning.
- Comparator Control
- Serum amylase levels will be compared between surviving and non-surviving patients with PQ poisoning.
- Main Outcome
- 28-day mortality.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Prognostic, Systematic review
- Keyword
- Amylases; Herbicides; Humans; Paraquat
- Contact
- Yong Li [email protected]
- Organisational Affiliation
- cangzhou central hospital
- Funding Source
- No funding sources
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-08-07
- Registration Date
- 2018-08-22
- Anticipated Start Date
- 2018-08-27
- Anticipated Completion Date
- 2019-08-27
- Title Cn
- 血清淀粉酶预测急性百草枯中毒后死亡率：一项Meta分析
- Title En
- Serum amylase in predicting mortality after acute paraquat poisoning: a meta-analysis
- Bilingual Status
- complete