Meta AnalysisID 2207
癸酸诺龙对身体功能、身体成分和骨密度的影响：系统评价与Meta分析
CRD42022367273
- What is the impact of nandrolone decanoate on body composition (e.g., muscle mass, fat mass, bone mineral density) and physical function (muscle strength and physical performance measures) in human adults? - What is th
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2207
- Evidence Id
- 10765
- Core Evidence Id
- 10765
- Source Meta Analysis Id
- 2158
- Herb2 Meta Analysis Id
- HBMA002158
- Crd Id
- CRD42022367273
- Title
- Impact of nandrolone decanoate on physical function, body composition, and bone mineral density: a systematic review and meta-analysis
- Review Question
- - What is the impact of nandrolone decanoate on body composition (e.g., muscle mass, fat mass, bone mineral density) and physical function (muscle strength and physical performance measures) in human adults? - What is the optimal dose and duration of administration to provide meaningful and/or significant improvements to the outcomes of interests identified above? - Do individuals of different sex and age respond differently in response to nandrolone decanoate injections?
- Study Type Included
- Inclusion: Randomised Controlled Trials Exclusion: -Open-label RCTs -In vivo and in vitro studies. -Observational studies. -Human interventions including additional pharmacological means which improve physical fitness (i.e,, use of other anabolic androgenic steroids).
- Condition Being Studied
- Physical Function, Body Composition
- Participant
- Inclusion criteria: - Adults aged 18+ years irrespective of health condition Exclusion critera: - Healthy individuals - Observational studies - In vivo/in vitro studies
- Animal
- Human Disease Modelled
- Intervention
- Nandrolone decanoate irrespective of dose and duration
- Comparator Control
- Placebo or appropriate control. Interventions that also involve exercise training and/or a nutritional supplementation/manipulation will be also allowed only if they are followed by both groups in a given intervention.
- Main Outcome
- - Muscle mass (kg) - Lean soft tissue mass (kg) - Fat mass (kg)/Body fat % - Bone mineral density/content (kg) - Ηandgrip strength; isotonic/isometric (e.g. knee extension/flexion/Nm) and/or isoinertial dynamometry strength tests (e.g. repetition maximum strength tests) of either upper or lower body - 6-minute walking test (m) - SPPB (short physical performance battery) - Gait speed (m/s) - Timed up to go test - Other measures of muscle strength and function (i.e., bench press, deadlift, squat - short physical performance battery, balance, timed up and go test) Measures of effect (Standardised) Mean Difference
- Outcome Measure
- Additional Outcome
- - Falls risk - Health-related quality of Life Measures of effect (Standardised) Mean Difference
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Adult; Body Composition; Bone Density; Humans; Muscle Strength; Muscles; Nandrolone Decanoate; Physical Functional Performance
- Contact
- Konstantinos Prokopidis [email protected]
- Organisational Affiliation
- University of Liverpool
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-16
- Registration Date
- 2022-11-18
- Anticipated Start Date
- 2022-11-30
- Anticipated Completion Date
- 2023-06-30
- Title Cn
- 癸酸诺龙对身体功能、身体成分和骨密度的影响：系统评价与Meta分析
- Title En
- Impact of nandrolone decanoate on physical function, body composition, and bone mineral density: a systematic review and meta-analysis
- Bilingual Status
- complete