Meta AnalysisID 22
瓜拉那（巴西香可可）对心血管健康的影响：一项系统评价
CRD42018083312
Does consumption and/or supplementation of guarana have an action on cardiovascular health and control of risk factors in humans?
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Record Fields
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- Meta Analysis Id
- 22
- Evidence Id
- 8580
- Core Evidence Id
- 8580
- Source Meta Analysis Id
- 20
- Herb2 Meta Analysis Id
- HBMA000020
- Crd Id
- CRD42018083312
- Title
- Effects of guarana (Paullinia cupana) on cardiovascular healthy: a systematic review
- Review Question
- Does consumption and/or supplementation of guarana have an action on cardiovascular health and control of risk factors in humans?
- Study Type Included
- Randomized controlled trials will be considered as standard for evaluating the effects of different medical interventions. They should therefore be well designed so that the chances of bias are minimized.
- Condition Being Studied
- Guarana (Paullinia cupana), a Brazilian plant native to the Amazon region, presents great economic, social and therapeutic importance. Its seed has a significant antioxidant characteristic, due to the considerable presence of bioactive compounds such as catechins, epicatechins, proanthocyanidins, caffeine, and to a lesser extent, theophylline and theobromine, being therefore of scientific interest. The consumption of food sources of antioxidants may represent an approach in inhibiting the damage caused by excess free radicals, becoming an alternative in the prevention and control of cardiovascular diseases, and their associated complications. These diseases constitute one of the main causes of prolonged hospitalizations and are determinant in the allocation of public resources in hospitalizations in the country, significantly implicating the mortality rate in all Brazilian regions. The objective of this systematic review was to analyze and synthesize the main evidences generated by controlled and randomized clinical trials on the ingestion of guaraná (Paullinia cupana), which, through supplementation, encapsulated, powdered or other forms of administration, have implications for risk factors and cardiovascular health in humans.
- Participant
- They will be considered as human participants, regardless of age (children, adults and elderly), regardless of gender (female and male), cardiovascular disease with or without an association of risk factors (hypertension, high cholesterol, smokers, sedentary, and / or diabetics), making continuous use or not of associated drug treatment.
- Animal
- Human Disease Modelled
- Intervention
- Studies with administration or supplementation using guarana (Paullinia cupana) in their various forms of administration (powdered and diluted, by infusion or through single capsules or in combination with other compounds having similar active principles, in order to compare the effects of consumption). Administration may be done in divided doses (daily or weekly) or in a single dose (mega dose). Interventions with the presence of a control group will be considered, being considered the participants who received placebo or another type of intervention or no intervention.
- Comparator Control
- Not applicable.
- Main Outcome
- Randomized controlled trials, which relate and evaluate consumption and [or supplementation of guarana (Paullinia cupana) to the detriment of cardiovascular health; conducted in humans.
- Outcome Measure
- Additional Outcome
- The associated risk factors of cardiovascular health after consumption and or supplementation of guarana (Paullinia cupana).
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Caffeine; Cardiovascular System; Humans; Paullinia; Plant Extracts
- Contact
- Andressa Ferreira Campos [email protected]
- Organisational Affiliation
- University of Sao Paulo www.fsp.usp.br
- Funding Source
- CAPES
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2017-12-03
- Registration Date
- 2018-01-08
- Anticipated Start Date
- 2017-05-07
- Anticipated Completion Date
- 2018-06-03
- Title Cn
- 瓜拉那（巴西香可可）对心血管健康的影响：一项系统评价
- Title En
- Effects of guarana (Paullinia cupana) on cardiovascular healthy: a systematic review
- Bilingual Status
- complete