Meta AnalysisID 2063
铜稳态失调及其与线粒体动力学和生物合成的关系：一项系统评价
CRD42021272921
How do changes in copper homeostasis affect mitochondrial fusion and fission processes? How do changes in copper homeostasis affect mitochondrial biogenesis? Context and rationale Copper is an important metal for cell ac
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2063
- Evidence Id
- 10621
- Core Evidence Id
- 10621
- Source Meta Analysis Id
- 2004
- Herb2 Meta Analysis Id
- HBMA002004
- Crd Id
- CRD42021272921
- Title
- Copper dyshomeostasis and its relationship to mitochondrial dynamics and biogenesis: a systematic review
- Review Question
- How do changes in copper homeostasis affect mitochondrial fusion and fission processes? How do changes in copper homeostasis affect mitochondrial biogenesis? Context and rationale Copper is an important metal for cell activity because it acts as a cofactor and/or structural component of several enzymes. An alteration in the homeostasis of this metal can lead either to an accumulation of copper in organs such as the liver and brain, as seen in Wilson's disease, which is toxic, or to a decrease in its levels in tissues, leading to a deficiency, as in Menkes' disease. Also, some studies have observed an alteration in copper homeostasis in neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. In cells, it can be found in the cytoplasm and also inside organelles, and the main organelle that compartmentalizes copper is the mitochondria. Mitochondria is responsible for the greatest production of energy in the cells and, therefore, essential for the correct cell function. Mitochondria can form mitochondrial networks, and may fuse or fission from this, determining the mitochondrial fusion and fission processes, respectively. This process is called mitochondrial dynamics and, together with mitophagy and mitochondrial biogenesis, determines the number of mitochondria in a cell. Considering that copper present in low or high concentrations intracellularly can influence these processes, especially in pathologies where changes in the levels of this metal are observed, the objective of this systematic review is to verify the current knowledge on the influence of copper homeostasis on dynamics and in mitochondrial biogenesis.
- Study Type Included
- Inclusion criteria: There are no restrictions on the types of study design eligible for inclusion. Exclusion criteria: None.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Studies with animal models. Exclusion criteria: Studies using species that are not an animal model (as plants), in vitro, ex vivo and in silico studies and studies in humans will be excluded.
- Human Disease Modelled
- Relationship between copper dyshomeostasis and mitochondrial fusion/fission and mitochondrial biogenesis.
- Intervention
- Inclusion criteria: - Studies evaluating the effects of copper exposure; - Studies evaluating the effects of copper chelators; - Studies evaluating the effects of a diet deficient in copper. All timings, frequencies and dosages of treatments described above are eligible for inclusion. Exclusion criteria: Studies evaluating the effects of copper nanoparticles.
- Comparator Control
- Inclusion criteria: Control group: 1) Group that were not exposed to copper; 2) Group that were not exposed to a drug or diet that decrease copper levels. Exclusion criteria: Groups that were not mentioned in the inclusion criteria.
- Main Outcome
- Outcome Measure
- Inclusion criteria: Effects of copper dyshomeostasis in mitochondrial fusion/fission or mitochondrial biogenesis. Exclusion criteria: Effects of copper dyshomeostasis in proteins not related to mitochondrial fusion/fission or mitochondrial biogenesis; effects in proteins involved in mitochondrial fusion/fission or mitochondrial biogenesis but that is not related to copper dyshomeostasis.
- Additional Outcome
- Study Method
- Keyword
- Animals; Copper; Mitochondrial Dynamics
- Contact
- Viviane Glaser [email protected]
- Organisational Affiliation
- Universidade Federal de Santa Catarina, Centro de Ciências Rurais, Coordenadoria Especial de Ciências Biológicas e Agronômicas
- Funding Source
- CNPq
- Other Selection Criteria
- Inclusion criteria: Original articles that measured mRNA levels or content of proteins involved in mitochondrial fusion/fission or mitochondrial biogenesis in copper dyshomeostasis in experimental models will be included. Exclusion criteria: Original studies that analyzed the effects of copper dyshomeostasis but did not analyze mitochondrial fusion/fission or mitochondrial biogenesis, and studies that measured proteins involved in mitochondrial fusion/fission or mitochondrial biogenesis in animal models not related to copper dyshomeostasis will be excluded; as well as meta-analysis, reviews, abstracts, hypotheses and points of view.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Completed not published
- First Submission Date
- 2021-08-12
- Registration Date
- 2021-09-24
- Anticipated Start Date
- 2021-04-05
- Anticipated Completion Date
- 2022-08-12
- Title Cn
- 铜稳态失调及其与线粒体动力学和生物合成的关系：一项系统评价
- Title En
- Copper dyshomeostasis and its relationship to mitochondrial dynamics and biogenesis: a systematic review
- Bilingual Status
- complete