Meta AnalysisID 2037
血清肌酐预测百草枯中毒后死亡：一项Meta分析
CRD42022335006
we have ample data to explore the potential of serum creatinine as a predictor of mortality in patients with paraquat (PQ) poisoning.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 2037
- Evidence Id
- 10595
- Core Evidence Id
- 10595
- Source Meta Analysis Id
- 1980
- Herb2 Meta Analysis Id
- HBMA001980
- Crd Id
- CRD42022335006
- Title
- Serum creatinine in predicting mortality after paraquat poisoning ：a meta-analysis
- Review Question
- we have ample data to explore the potential of serum creatinine as a predictor of mortality in patients with paraquat (PQ) poisoning.
- Study Type Included
- Observational studies (prospective studies and retrospective studies) will be included.
- Condition Being Studied
- Paraquat (PQ, 1, 1′-dimethyl-4, 4′-bipyridinium dichloride) is a quaternary nitrogen herbicide used worldwide that exerts strong toxic effects on humans and animals. Being inexpensive and easily accessible, it has become the herbicide with the highest acute poisoning mortality rate. Management of PQ poisoning has remained predominantly supportive and the results for the treatment of PQ poisoning, including immunosuppressive therapy, prolonged extracorporeal elimination and lung transplantation, need to been further confirmed. If not treated in time, PQ accumulation in the body leads to fulminant organ failure, including pulmonary edema, cardiac, kidney, and hepatic failure. Therefore, confirming the PQ-poisoning diagnosis and risk assessment in a timely manner is particularly important. PQ induces acute tubular necrosis due to direct toxicity to the proximal tubule. Other factors influencing the development of acute kidney injury include hypoperfusion from hypovolaemia and/or hypotension and direct glomerular injury. Recently, serum creatinine was been used to predict the prognosis and mortality of patients with PQ poisoning, although its prognostic accuracy for patients with PQ poisoning has not been fully determined. Therefore, we will conduct this a meta-analysis to evaluate the value of serum creatinine as a predictor of mortality in patients with PQ poisoning.
- Participant
- Patients with PQ poisoning.
- Animal
- Human Disease Modelled
- Intervention
- Serum creatinine as a predictor of mortality after paraquat poisoning.
- Comparator Control
- Serum creatinine levels will be compared between surviving and non-surviving patients with PQ poisoning.
- Main Outcome
- 90-day mortality. Measures of effect Odds ratio (OR) and 95% confidence intervals(Cls).
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Diagnostic, Meta-analysis, Prognostic, Systematic review
- Keyword
- Creatinine; Humans; Paraquat; Prognosis
- Contact
- Wei Huang [email protected]
- Organisational Affiliation
- Zhejiang University, Hangzhou The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou
- Funding Source
- None Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-05-24
- Registration Date
- 2022-06-04
- Anticipated Start Date
- 2022-05-01
- Anticipated Completion Date
- 2022-12-01
- Title Cn
- 血清肌酐预测百草枯中毒后死亡：一项Meta分析
- Title En
- Serum creatinine in predicting mortality after paraquat poisoning ：a meta-analysis
- Bilingual Status
- complete