Meta AnalysisID 2033
阴道液尿素与肌酐诊断胎膜早破：一项系统评价
CRD42020141800
Are urea and creatinine in vaginal sample reliable to diagnose the premature rupture of membranes?
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Record Fields
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- Meta Analysis Id
- 2033
- Evidence Id
- 10591
- Core Evidence Id
- 10591
- Source Meta Analysis Id
- 1976
- Herb2 Meta Analysis Id
- HBMA001976
- Crd Id
- CRD42020141800
- Title
- Vaginal fluid urea and creatinine in the diagnosis of premature rupture of membranes. A systematic review
- Review Question
- Are urea and creatinine in vaginal sample reliable to diagnose the premature rupture of membranes?
- Study Type Included
- All published case-control and cohort studies.
- Condition Being Studied
- Premature rupture of membranes (PROM) occurs in 10% of all pregnancies and about 2–4% of preterm pregnancies. PROM refers to rupture of the fetal membranes prior to the onset of labor and can occur at any gestational age. PROM is associated with adverse complications for the mother and the neonate such as chorioamnionitis, placental abruption, preterm birth and postpartum infection. Therefore, the diagnosis of PROM is of particular importance.
- Participant
- Pregnant women who are complaining of vaginal fluid leakage between 20 and 41 weeks of gestation.
- Animal
- Human Disease Modelled
- Intervention
- Urea plays an important role in the metabolism of nitrogen-containing compounds in the urine. Creatinine is a break-down product of creatinine phosphate in muscles and is usually produced at a fairly constant rate and is mainly filtered out of the blood by kidneys. Fetal urine is the most important source of amniotic fluid in the second and third trimester of pregnancy. Thus urea and creatinine of vaginal fluid may be helpful in diagnosing of PROM.
- Comparator Control
- The control group are women without PROM.
- Main Outcome
- Mean value of urea measured by enzymatic urease method and mean value of creatinine measured by Jaffe method. Measures of effect Second and third trimester.
- Outcome Measure
- Additional Outcome
- None Measures of effect Neonatal period and postpartum period
- Study Method
- Diagnostic, Meta-analysis, Prevention, Systematic review
- Keyword
- Body Fluids; Creatinine; Female; Fetal Membranes, Premature Rupture; Humans; Pregnancy; Premature Birth; Urea
- Contact
- Fatemeh Malchi [email protected]
- Organisational Affiliation
- Midwifery Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Iran
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-07-14
- Registration Date
- 2020-02-05
- Anticipated Start Date
- 2019-06-01
- Anticipated Completion Date
- 2020-08-20
- Title Cn
- 阴道液尿素与肌酐诊断胎膜早破：一项系统评价
- Title En
- Vaginal fluid urea and creatinine in the diagnosis of premature rupture of membranes. A systematic review
- Bilingual Status
- complete