Meta AnalysisID 2009
使用香豆素衍生物或直接口服抗凝药患者服药依从性的相关因素：系统评价
CRD42020223555
What are the factors associated with medication adherence employing coumarin derivatives or direct oral anticoagulants?
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Record Fields
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- Meta Analysis Id
- 2009
- Evidence Id
- 10567
- Core Evidence Id
- 10567
- Source Meta Analysis Id
- 1952
- Herb2 Meta Analysis Id
- HBMA001952
- Crd Id
- CRD42020223555
- Title
- Associated factors of medication adherence employing coumarin derivatives or direct oral anticoagulants: a systematic review
- Review Question
- What are the factors associated with medication adherence employing coumarin derivatives or direct oral anticoagulants?
- Study Type Included
- Observational studies (cross-sectional, case-control, cohort studies) and intervention studies in humans (clinical trials).
- Condition Being Studied
- Thrombosis is a mechanism for the development of diseases responsible for high rates of health complications and mortality, such as acute myocardial infarction, ischemic stroke and venous thromboembolism (VTE). Thrombosis can be of the arterial type (ischemic heart disease and ischemic stroke) or venous (deep vein thrombosis and pulmonary embolism). Cardiovascular diseases (CVD), such as atrial fibrillation (AF), present a five-fold increased risk of developing stroke, which is the third leading cause of death worldwide. Among other cardiovascular complications in patients with heart valve implants, it is possible to obstruct the valve due to thrombus formation and, due to this risk, anticoagulation may be indicated. Thus, primary and secondary thromboprophylaxis is performed to reduce the risk of developing negative outcomes with the occurrence of thromboembolisms, including mortality. Thromboprophylaxis is performed using anticoagulants, e.g. coumarin derivatives and direct oral anticoagulants (DOACs).
- Participant
- Patients with ≥18 years of age, of both sexes, on oral anticogulation for any indication of primary or secondary thromboprophylaxis.
- Animal
- Human Disease Modelled
- Intervention
- Oral anticoagulation with coumarin derivatives or direct oral anticoagulants.
- Comparator Control
- Not applicable.
- Main Outcome
- The assessment of adherence of the oral anticoagulation therapy in any of the phases will be considered: initiation, implementation and persistence. • Initiation: administration of the first prescribed dose; • Implementation: dose administration corresponds effectively to that prescribed from initiation to the last dose; • Persistence: the period between initiation and discontinuation. As methods to measure adherence, direct (measures of the concentration of the drug or metabolites in fluids such as blood and urine or of biological markers in the blood) and indirect (electronic monitoring devices, evaluation of clinical response, pill count, application of questionnaires and self-report of treatment adherence) methods will be considered. Measures of effect The main measures of effect for the main outcomes include relative risks, odds ratios and risk differences.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Anticoagulants; Coumarins; Humans; Medication Adherence
- Contact
- Maria Martins [email protected]
- Organisational Affiliation
- Universidade Federal de Minas Gerais (UFMG)
- Funding Source
- This study was financed in part by the Coordination of Improvement of Higher Education Personnel - Brazil (CAPES) - Finance Code 001.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-11-30
- Registration Date
- 2020-12-31
- Anticipated Start Date
- 2020-10-02
- Anticipated Completion Date
- 2021-06-15
- Title Cn
- 使用香豆素衍生物或直接口服抗凝药患者服药依从性的相关因素：系统评价
- Title En
- Associated factors of medication adherence employing coumarin derivatives or direct oral anticoagulants: a systematic review
- Bilingual Status
- complete