Meta AnalysisID 1941
对乙酰氨基酚联合可待因对比对乙酰氨基酚联合安慰剂用于第三磨牙手术后镇痛的疗效：一项系统评价
CRD42020201054
What is the effectiveness of codeine associated with paracetamol compared to paracetamol with placebo for pain relief in third molar surgery?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1941
- Evidence Id
- 10499
- Core Evidence Id
- 10499
- Source Meta Analysis Id
- 1884
- Herb2 Meta Analysis Id
- HBMA001884
- Crd Id
- CRD42020201054
- Title
- Effectiveness of paracetamol associated with codeine compared to paracetamol with placebo for pain relief in third molar surgery: a systematic review
- Review Question
- What is the effectiveness of codeine associated with paracetamol compared to paracetamol with placebo for pain relief in third molar surgery?
- Study Type Included
- Clinical trials that demonstrate the use of paracetamol with codeine in the pre and / or postoperative period of surgery on third molars
- Condition Being Studied
- The removal of third molars is a common practice in dentistry, depending on the case and the classification is complex, the removal or even before undergoing the surgical procedure may already be impacted, causing a post- operative that can cause pain and discomfort to the patient. Various pharmacological combinations with different mechanisms are used in an attempt to relieve the patient's pain. In this context, paracetamol combined with codeine is a widely used drug for pain relief in post-surgical. However, due to the fact that codeine being an opioid can cause side effects and adverse effects, and their use often can cause dependence this way.
- Participant
- Clinical trial articles that evaluated male and female patients who underwent third molar surgery over the age of 18.
- Animal
- Human Disease Modelled
- Intervention
- To determine the effectiveness of codeine associated with paracetamol
- Comparator Control
- The comparison will be the use of paracetamol with placebo for pain relief in third molar surgery.
- Main Outcome
- Occurrence of postoperative pain Measures of effect Occurrence will be reported in percentage.
- Outcome Measure
- Additional Outcome
- Secondary variables: Need for escape analgesia, type of anesthetic used in surgery, duration of preservation, total number of paracetamol-codeine tablets with the same formulation taken by the patient in relation to pain symptoms, incidence of adverse effects in each group of patients. study during the study period. Complementary variables: Age range, type of anesthetic used in surgery, and antibiotic therapy. Measures of effect The effect measures will be according to the studies
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Acetaminophen; Analgesics, Non-Narcotic; Codeine; Humans; Molar, Third; Pain
- Contact
- Noemi de Oliveira Souto [email protected]
- Organisational Affiliation
- Pythagoras College of Uberlandia
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English, Portuguese-Brazil
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-07-28
- Registration Date
- 2020-08-28
- Anticipated Start Date
- 2020-08-01
- Anticipated Completion Date
- 2021-02-01
- Title Cn
- 对乙酰氨基酚联合可待因对比对乙酰氨基酚联合安慰剂用于第三磨牙手术后镇痛的疗效：一项系统评价
- Title En
- Effectiveness of paracetamol associated with codeine compared to paracetamol with placebo for pain relief in third molar surgery: a systematic review
- Bilingual Status
- complete