Meta AnalysisID 1938
对乙酰氨基酚（扑热息痛）联用或不联用可待因或双氢可待因治疗成人神经病理性疼痛[Cochrane方案]
CRD42016045967
To assess the analgesic efficacy and adverse events of paracetamol with or without codeine or dihydrocodeine for chronic neuropathic pain in adults.
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Record Fields
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- Meta Analysis Id
- 1938
- Evidence Id
- 10496
- Core Evidence Id
- 10496
- Source Meta Analysis Id
- 1881
- Herb2 Meta Analysis Id
- HBMA001881
- Crd Id
- CRD42016045967
- Title
- Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults [Cochrane Protocol]
- Review Question
- To assess the analgesic efficacy and adverse events of paracetamol with or without codeine or dihydrocodeine for chronic neuropathic pain in adults.
- Study Type Included
- We will include randomised controlled trials (RCTs) with double-blind assessment of participant outcomes following two weeks or more of treatment, although the emphasis of the review will be on studies with a duration of eight weeks or longer. We require full journal publication, with the exception of online clinical trial results summaries of otherwise unpublished clinical trials and abstracts with sufficient data for analysis. We will not include short abstracts (usually meeting reports). We will exclude studies that are non-randomised, studies of experimental pain, case reports, and clinical observations.
- Condition Being Studied
- The Cochrane Pain, Palliative and Supportive Care Group
- Participant
- Studies will include adults aged 18 years and above with one or more chronic neuropathic pain condition including (but not limited to):<ol> cancer-related neuropathy; central neuropathic pain; complex regional pain syndrome (CRPS) Type II; human immunodeficiency virus (HIV) neuropathy; painful diabetic neuropathy (PDN); phantom limb pain; postherpetic neuralgia (PHN); postoperative or traumatic neuropathic pain; spinal cord injury; trigeminal neuralgia.</ol> Where we include studies of participants with more than one type of neuropathic pain, we will analyse results according to the primary condition.
- Animal
- Human Disease Modelled
- Intervention
- Oral paracetamol with or without codeine or dihydrocodeine, at any dose, administered for the relief of neuropathic pain and compared with placebo or any active comparator.
- Comparator Control
- Oral paracetamol with or without codeine or dihydrocodeine, at any dose, administered for the relief of neuropathic pain and compared with placebo or any active comparator.
- Main Outcome
- <ol> Participant-reported pain relief of 30% or greater. Participant-reported pain relief of 50% or greater. PGIC much or very much improved. PGIC very much improved. </ol>
- Outcome Measure
- Additional Outcome
- <ol> Any pain-related outcome indicating some improvement. Withdrawals due to lack of efficacy, adverse events, and for any cause. Participants experiencing any adverse event. Participants experiencing any serious adverse event. Serious adverse events typically include any untoward medical occurrence or effect that at any dose results in death, is life-threatening, requires hospitalisation or prolongation of existing hospitalisation, results in persistent or significant disability or incapacity, is a congenital anomaly or birth defect, is an 'important medical event' that may jeopardise the patient, or may require an intervention to prevent one of the above characteristics or consequences. Specific adverse events, particularly somnolence and dizziness. </ol>
- Study Method
- Intervention, Systematic review
- Keyword
- Acetaminophen; Adult; Analgesics, Non-Narcotic; Codeine; Drug Therapy; Drug Therapy, Combination; Humans; Neuralgia; Pain; Pain Management; Treatment Outcome
- Contact
- R Andrew Moore [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- The National Institute for Health Research (NIHR), Oxford Pain Relief Trust
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2016-08-15
- Anticipated Start Date
- 2016-06-15
- Anticipated Completion Date
- 2016-12-31
- Title Cn
- 对乙酰氨基酚（扑热息痛）联用或不联用可待因或双氢可待因治疗成人神经病理性疼痛[Cochrane方案]
- Title En
- Paracetamol (acetaminophen) with or without codeine or dihydrocodeine for neuropathic pain in adults [Cochrane Protocol]
- Bilingual Status
- complete