Meta AnalysisID 1937
可待因对比安慰剂治疗儿童慢性咳嗽[Cochrane方案]
CRD42016033604
To evaluate the safety and efficacy of codeine (and derivatives) for the treatment of chronic cough in children.
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Record Fields
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- Meta Analysis Id
- 1937
- Evidence Id
- 10495
- Core Evidence Id
- 10495
- Source Meta Analysis Id
- 1880
- Herb2 Meta Analysis Id
- HBMA001880
- Crd Id
- CRD42016033604
- Title
- Codeine versus placebo for chronic cough in children [Cochrane Protocol]
- Review Question
- To evaluate the safety and efficacy of codeine (and derivatives) for the treatment of chronic cough in children.
- Study Type Included
- We will include randomised controlled trials (RCTs), quasi-RCTs and stratified RCTs that compare codeine (or derivatives) versus placebo. We will include studies reported as full-text, those published as abstract only, and unpublished data.
- Condition Being Studied
- The Cochrane Airways Group
- Participant
- Due to the differing definitions and aetiology of chronic cough between children and adults, we will only include studies with children aged 18 years or younger with a diagnosis of chronic cough (cough lasting ≥ 4 weeks). We will exclude participants with acute cough.
- Animal
- Human Disease Modelled
- Intervention
- We will include studies comparing medications that contain codeine or codeine derivatives versus placebo. We will include the following derivative agents: dihydrocodeine, nalodeine, azidocodeine, acetylcodeine, dextromethorphan, nicocodine, pholcodine, alpha-codeimethine, 6-succinylcodeine, 6-codeinone, 14-hydroxycodeine, n-methylcodinium iodine, codeine-7,8-oxide, codeine-6-glucronide and O(6)-codeine methyl ether. We will include the following comparisons:<ol> Cough mixture containing codeine or codeine derivative only as the active ingredient versus placebo. Cough mixture containing codeine or codeine derivative plus other active ingredient/s versus cough mixture containing placebo plus the same other active ingredient/s.</ol>
- Comparator Control
- We will include studies comparing medications that contain codeine or codeine derivatives versus placebo. We will include the following comparisons: Cough mixture containing codeine or codeine derivative only as the active ingredient versus placebo. Cough mixture containing codeine or codeine derivative plus other active ingredient/s versus cough mixture containing placebo plus the same other active ingredient/s.
- Main Outcome
- Primary outcomes are those that reflect objective measures of treatment superiority, non-inferiority, or inferiority, and include:<ol> Number of children not cured at follow-up; Number of children who experience a reduction in cough severity (clinically defined as a > 70% change in severity as per previous RCTs) (Chang 1998; Marchant 2012); Serious adverse events (a reaction to the study drug that results in hospital admission and or loss of life).</ol>
- Outcome Measure
- Additional Outcome
- The following secondary outcome measures contribute to the strength of primary outcome analysis:<ol> Symptoms and burden of cough as reported in cough indices such as cough quality of life scores, diary card and cough severity index scores. Adverse events/side-effects (any event that is not considered life-threatening and does not result in a hospital admission and would otherwise not occur without exposure to the study medication).</ol> Reporting one of more of the outcomes listed above in the trial is not an inclusion criterion for the review.
- Study Method
- Keyword
- Antitussive Agents; Child; Chronic Disease; Codeine; Cough; Humans; Treatment Outcome
- Contact
- Samantha J Gardiner [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- Lung Foundation of Australia/Australian Satellite of the Cochrane Airways Group Scholarship to SG, National Health and Medical Research Council (NHMRC), The authors declare that no such funding was received for this systematic review, Queensland University of Technology, Lung Foundation of Australia/Australian Satellite of the Cochrane Airways Group Scholarship to SG, National Health and Medical Research Council (NHMRC), The authors declare that no such funding was received for this systematic review, Queensland University of Technology
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2016-01-25
- Anticipated Start Date
- 2015-10-15
- Anticipated Completion Date
- 2017-10-15
- Title Cn
- 可待因对比安慰剂治疗儿童慢性咳嗽[Cochrane方案]
- Title En
- Codeine versus placebo for chronic cough in children [Cochrane Protocol]
- Bilingual Status
- complete