Meta AnalysisID 1935
吗啡、芬太尼、羟考酮或可待因用于治疗癌痛时对患者意识、食欲和口渴的影响[Cochrane方案]
CRD42015018975
To determine the impact, as reported in randomised controlled trials, on patient consciousness, appetite and thirst of morphine, fentanyl, oxycodone or codeine when used to treat cancer pain.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 1935
- Evidence Id
- 10493
- Core Evidence Id
- 10493
- Source Meta Analysis Id
- 1878
- Herb2 Meta Analysis Id
- HBMA001878
- Crd Id
- CRD42015018975
- Title
- Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain [Cochrane Protocol]
- Review Question
- To determine the impact, as reported in randomised controlled trials, on patient consciousness, appetite and thirst of morphine, fentanyl, oxycodone or codeine when used to treat cancer pain.
- Study Type Included
- We will examine all studies that have been included in Cochrane reviews of morphine (Wiffen 2013), fentanyl (Hadley 2012) oxycodone (Schmidt-Hansen 2010) and codeine (Schremmer 2013) for cancer pain. For inclusion in the individual reviews, studies were: randomised controlled trials (RCTs), single or multiple dose, parallel or cross-over design, and of any duration. Studies that did not state that they were randomised were excluded, as were quasi-randomised studies, studies with fewer than 10 participants (Moore 1998), and studies that did not deal with cancer-related pain, or did not assess pain as an outcome measure. Studies reported only as short abstracts only (usually from meetings) were not included because they contain insufficient information to assess methodological quality and risk of bias.
- Condition Being Studied
- The Cochrane Pain, Palliative and Supportive Care Group
- Participant
- Adults and children with cancer pain requiring treatment with opioids.
- Animal
- Human Disease Modelled
- Intervention
- Morphine, fentanyl, oxycodone or codeine for cancer pain preparations compared with either placebo, an alternative formulation of morphine or an active control. Any route of administration was permitted, though morphine, codeine and oxycodone were likely to be used by the oral route of administration, while fentanyl use is almost always through transdermal patches.
- Comparator Control
- Placebo, an alternative formulation of morphine or an active control.
- Main Outcome
- This review will focus on adverse events that affect patient consciousness or patient appetite or thirst. We will also look for surrogate outcomes including: delirium, dizziness , hallucinations, mood change and somnolence that may relate to patient consciousness, and nausea, vomiting, constipation, diarrhoea, dyspepsia, dysphagia, anorexia or dry mouth that may relate to appetite or thirst. Where studies report these adverse effects, we will look to see if concomitant medication could also have contributed.
- Outcome Measure
- Additional Outcome
- None.
- Study Method
- Keyword
- Analgesics, Opioid; Appetite; Codeine; Consciousness; Fentanyl; Humans; Morphine; Neoplasms; Oxycodone; Pain; Thirst
- Contact
- Philip J Wiffen [email protected]
- Organisational Affiliation
- The Cochrane Collaboration http://www.cochrane.org/
- Funding Source
- Oxford Pain Relief Trust, NIHR Incentive Award (Reference: 13/180/08), Oxford Pain Relief Trust, NIHR Incentive Award (Reference: 13/180/08)
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Ongoing
- First Submission Date
- Registration Date
- 2015-03-27
- Anticipated Start Date
- 2014-03-15
- Anticipated Completion Date
- 2016-04-15
- Title Cn
- 吗啡、芬太尼、羟考酮或可待因用于治疗癌痛时对患者意识、食欲和口渴的影响[Cochrane方案]
- Title En
- Impact of morphine, fentanyl, oxycodone or codeine on patient consciousness, appetite and thirst when used to treat cancer pain [Cochrane Protocol]
- Bilingual Status
- complete